Novel mechanisms of Fn14 signalling and its regulation

Abstract

This study investigated the molecular mechanisms regulating TWEAKindependent Fn14 signalling to identify barriers preventing successful targeting of the TWEAK/Fn14 signalling pathway. The principal discovery was that alternative splicing produces a novel Fn14 Isoform, called Fn14 Isoform 2, which has the capacity to activate in the absence of TWEAK.