Novel mechanisms of Fn14 signalling and its regulation
| dc.contributor.author | Main, Nathan Michael | |
| dc.contributor.supervisor | Nina Tirnitz-Parker | en_US |
| dc.contributor.supervisor | Ben Dwyer | en_US |
| dc.contributor.supervisor | Pieter Eichhorn | en_US |
| dc.date.accessioned | 2024-10-15T05:30:49Z | |
| dc.date.available | 2024-10-15T05:30:49Z | |
| dc.date.issued | 2024 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/96122 | |
| dc.description.abstract |
This study investigated the molecular mechanisms regulating TWEAKindependent Fn14 signalling to identify barriers preventing successful targeting of the TWEAK/Fn14 signalling pathway. The principal discovery was that alternative splicing produces a novel Fn14 Isoform, called Fn14 Isoform 2, which has the capacity to activate in the absence of TWEAK. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Novel mechanisms of Fn14 signalling and its regulation | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | Curtin Medical School | en_US |
| curtin.accessStatus | Fulltext not available | en_US |
| curtin.faculty | Health Sciences | en_US |
| curtin.contributor.orcid | Main, Nathan Michael [0000-0003-0966-0745] | en_US |
| dc.date.embargoEnd | 2026-10-02 |