Show simple item record

dc.contributor.authorCasciano, Fabio
dc.contributor.authorCaruso, Lorenzo
dc.contributor.authorZauli, Enrico
dc.contributor.authorGonelli, Arianna
dc.contributor.authorZauli, Giorgio
dc.contributor.authorVaccarezza, Mauro
dc.date.accessioned2024-12-13T02:34:00Z
dc.date.available2024-12-13T02:34:00Z
dc.date.issued2024
dc.identifier.citationCasciano, F. and Caruso, L. and Zauli, E. and Gonelli, A. and Zauli, G. and Vaccarezza, M. 2024. Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. Biomedicines. 12 (11): pp. 2528-.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/96559
dc.identifier.doi10.3390/biomedicines12112528
dc.description.abstract

The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind these effects are still not fully understood. To contribute to our comprehension of exercise's impact on cancer immunotherapy and provide recommendations for future research in exercise oncology, we will examine the roles and underlying mechanisms of exercise on immune cells. In addition to reducing the likelihood of developing cancer, exercise can also improve the effectiveness of certain approved anticancer treatments, such as targeted therapy, immunotherapy, and radiotherapy. Exercise is a pivotal modulator of the immune response, and thus, it can play an emerging important role in new immunotherapies. The mechanisms responsible for these effects involve the regulation of intra-tumoral angiogenesis, myokines, adipokines, their associated pathways, cancer metabolism, and anticancer immunity. Our review assesses the potential of physical exercise as an adjuvant/neoadjuvant tool, reducing the burden of cancer relapse, and analyzes emerging molecular mechanisms predicting favorable adjuvanticity effects.

dc.languageeng
dc.subjectimmune response
dc.subjectimmunotherapy
dc.subjectlifestyle
dc.subjectoncology
dc.subjectphysical exercise
dc.subjecttumor microenvironment
dc.titleEmerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy.
dc.typeJournal Article
dcterms.source.volume12
dcterms.source.number11
dcterms.source.startPage2528
dcterms.source.issn2227-9059
dcterms.source.titleBiomedicines
dc.date.updated2024-12-13T02:33:58Z
curtin.departmentCurtin Medical School
curtin.accessStatusIn process
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
dcterms.source.eissn2227-9059
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]
curtin.repositoryagreementV3


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record