The Effects of S-Allyl-Cysteine and Cannabidiol on Cerebral and Retinal Neurovascular Integrity and Cognitive Function in Type 2 Diabetes

Majimbi, Maimuna

Majimbi M 2024 Public.pdf (21.26Mb)

Access Status

Open access

Authors

Majimbi, Maimuna

Date

2024

Supervisor

Ryu Takechi

John Mamo

Virginie Lam

Type

Thesis

Award

PhD

Metadata

Show full item record

Faculty

Health Sciences

School

School of Population Health

URI

http://hdl.handle.net/20.500.11937/96642

Collection

Curtin Theses

Abstract

Type 2 diabetes (T2D) induces cognitive dysfunction through neurovascular, inflammatory, and oxidative mechanisms. This thesis explores the therapeutic potential of S-allyl-cysteine (SAC) and cannabidiol (CBD) in mitigating these pathophysiologies, comparing their neuroprotective efficacy against metformin. Utilising the clinically relevant db/db mouse model, it reveals that retinal changes mirror brain pathology and can predict cognitive decline. Dietary provision of SAC and CBD showed significant neuroprotective effects, suggesting promising strategies for managing T2D-related cognitive and retinal complications with natural compounds.