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    Nutritional status, growth and disease management in children with single and dual diagnosis of type 1 diabetes mellitus and coeliac disease

    Access Status
    Open access via publisher
    Authors
    Mackinder, M.
    Allison, G.
    Svolos, V.
    Buchanan, E.
    Johnston, A.
    Cardigan, T.
    Laird, N.
    Duncan, H.
    Fraser, K.
    Edwards, Christine
    Craigie, I.
    McGrogan, P.
    Gerasimidis, K.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mackinder, M. and Allison, G. and Svolos, V. and Buchanan, E. and Johnston, A. and Cardigan, T. and Laird, N. et al. 2014. Nutritional status, growth and disease management in children with single and dual diagnosis of type 1 diabetes mellitus and coeliac disease. BMC Gastroenterology. 14 (1).
    Source Title
    BMC Gastroenterology
    DOI
    10.1186/1471-230X-14-99
    URI
    http://hdl.handle.net/20.500.11937/9736
    Collection
    • Curtin Research Publications
    Abstract

    Background: The consequences of subclinical coeliac disease (CD) in Type 1 diabetes mellitus (T1DM) remain unclear. We looked at growth, anthropometry and disease management in children with dual diagnosis (T1DM + CD) before and after CD diagnosis.Methods: Anthropometry, glycated haemoglobin (HbA1c) and IgA tissue transglutaminase (tTg) were collected prior to, and following CD diagnosis in 23 children with T1DM + CD. This group was matched for demographics, T1DM duration, age at CD diagnosis and at T1DM onset with 23 CD and 44 T1DM controls.Results: No differences in growth or anthropometry were found between children with T1DM + CD and controls at any time point. Children with T1DM + CD, had higher BMI z-score two years prior to, than at CD diagnosis (p < 0.001). BMI z-score change one year prior to CD diagnosis was lower in the T1DM + CD than the T1DM group (p = 0.009). At two years, height velocity and change in BMI z-scores were similar in all groups. No differences were observed in HbA1c between the T1DM + CD and T1DM groups before or after CD diagnosis. More children with T1DM + CD had raised tTg levels one year after CD diagnosis than CD controls (CDx to CDx + 1 yr; T1DM + CD: 100% to 71%, p = 0.180 and CD: 100% to 45%, p < 0.001); by two years there was no difference.Conclusions: No major nutrition or growth deficits were observed in children with T1DM + CD. CD diagnosis does not impact on T1DM glycaemic control. CD specific serology was comparable to children with single CD, but those with dual diagnosis may need more time to adjust to gluten free diet. © 2014 Mackinder et al.

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