Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method
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Objective: To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. Design: Subjects with knee OA (Kellgren & Lawrence grade ≥2) and controls without OA (both n = 26, seven women) were matched by sex, age, body mass index and compartment. The VOT method was applied to TB X-ray images and fractal signature and dimension in horizontal (FSH, FDH) and vertical (FSV, FDV) directions and along the roughest part of TB (FSSta, FDSta), texture aspect ratio (Str) and signature (StrS), and mean FD (FDMEAN) were calculated. The VOT method was compared against an augmented Hurst orientation transform (HOT) method using paired t tests, intraclass correlation coefficients (ICCs) and coefficients of variation (CVs%). Longitudinal sensitivity to OA bone changes was not assessed. Results: For the reproducibility of texture parameters, ICCs were >0.75 and CVs% were <8.2% for both methods. Compared with controls, FDMEAN, FDH, FDV and FDSta for OA knees were lower (P < 0.001), while Str was higher in both medial (P = 0.03) and lateral (P = 0.02) compartments. FSH, FSSta were lower for OA knees than for controls at sizes 0.3–0.7 mm (P < 0.001) in both compartments. In lateral compartment, FSV for OA knees was lower than for controls at sizes 0.3–0.5 mm (P < 0.001) and 0.55–0.70 mm (P < 0.02), while in medial compartment at sizes 0.3–0.7 mm (P < 0.001). Compared with controls, StrS for OA knees was higher at sizes 0.3, 0.55–0.70 mm in medial (P < 0.03) and lateral (P < 0.04) compartments.Conclusions: The VOT method is comparable to HOT method in the reproducibility of texture parameters and the ability to discriminate between non-OA and OA TB textures. However, unlike the HOT method, it quantifies texture roughness along the roughest part of the tibial bone, texture anisotropy at individual trabecular sizes and it works over a larger range of trabecular sizes. The VOT method may be a valuable tool for studying OA changes in TB.
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Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by fractal methodsPodsiadlo, Pawel; Dahl, L; Englund, M; Lohmander, L; Stachowiak, Gwidon (2008)Objective: To develop an accurate method for quantifying differences in the trabecular structure in the tibial bone between subjects with and without knee osteoarthritis (OA). Methods: Standard knee radiographs were taken ...
Trabecular bone texture detected by plain radiography and variance orientation transform method is different between knees with and without cartilage defectsWolski, Marcin; Stachowiak, Gwidon; Dempsey, A; Mills, P; Cicuttini, F; Wang, Y; Stoffel, K; Lloyd, D; Podsiadlo, Pawel (2011)The objective of this work is to evaluate differences in trabecular bone (TB) texture between subjects with and without tibiofemoral cartilage defects using a variance orientation transform (VOT) method. A case–control ...
Woloszynski, Tomasz; Podsiadlo, Pawel; Stachowiak, Gwidon; Kurzynski, M.; Lohmander, L.; Englund, M. (2012)Objective: To develop a system for predicting the progression of radiographic knee osteoarthritis (OA) using tibial trabecular bone texture. Methods: We studied 203 knees with (n = 68) or without (n = 135) radiographic ...