Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk
| dc.contributor.author | D'Alonzo, Zachary John | |
| dc.contributor.supervisor | John Mamo | en_US |
| dc.contributor.supervisor | Virginie Lam | en_US |
| dc.contributor.supervisor | Ryu Takechi | en_US |
| dc.date.accessioned | 2025-05-13T01:12:21Z | |
| dc.date.available | 2025-05-13T01:12:21Z | |
| dc.date.issued | 2025 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/97724 | |
| dc.description.abstract |
Two main risk factors for Alzheimer’s Disease are the APOE4 gene and a diet high in saturated fat. Additionally, the protein amyloid-beta is a primary pathological characteristic of Alzheimer’s Disease. This thesis demonstrates a vascular axis of Alzheimer’s Disease risk. Following a high-fat meal, humans exhibited elevated levels of amyloid-beta in the blood, with a further increase observed in individuals carrying the APOE4 gene. Notably, this elevation was more pronounced after the consumption of saturated fats compared to unsaturated fats. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | School of Population Health | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |
| curtin.contributor.orcid | D'Alonzo, Zachary John [0000-0003-0681-1798] | en_US |