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    Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With “Western or Eastern Environments/Lifestyles”

    221081_129621_Maternal_Genetic_Variants_of_IL4_IL13_Pathway_Genes_on_IgE.pdf (271.9Kb)
    Access Status
    Open access
    Authors
    Zhang, Guicheng
    Khoo, S.
    Makela, M.
    Candelaria, P.
    Hayden, C.
    von Hertzen, L.
    Laatikainen, T.
    Vartiainen, E.
    Goldblatt, J.
    Haahtela, T.
    LeSouef, P.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Zhang, G. and Khoo, S. and Makela, M. and Candelaria, P. and Hayden, C. and Hertzen, L. and Laatikainen, T. et al. 2014. Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With “Western or Eastern Environments/Lifestyles”. Allergy, Asthma & Immunology Research. 6 (4): pp. 350-356.
    Source Title
    Allergy, Asthma & Immunology Research
    DOI
    10.4168/aair.2014.6.4.350
    ISSN
    2092-7363
    School
    School of Public Health
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc/3.0/

    URI
    http://hdl.handle.net/20.500.11937/9802
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: We investigated maternal genetic effects of four IL-4/IL-13 pathway genes as well as their interactions with the "Western or Eastern lifestyles/environments" on IgE in Karelian children. Methods: This study included 609 children and their mothers. Total IgE levels in children and mothers were measured and 10 single nucleotide polymorphisms (SNPs) in IL-4, IL-4Ra, IL-13, and STAT6 were genotyped in mothers and their children. Results: The maternal G allele of IL-13 130 (rs20541) was significantly (P=0.001) associated with decreased IgE in children in the Karelian population (Pooling Finnish and Russian children), as well as in Finnish (P=0.030) and Russian children (P=0.018). The IgE levels were significantly (P=0.001) higher in Russian children whose mothers were homozygous for the G allele of the IL-4Ra 50 (rs1805010) SNP than that in Russian children of mothers who were AG heterozygotes or AA homozygotes. After accounting for children's genotypes, we observed interactive effects on children's IgE for maternal IL-13 130 genotypes (P=0.014) and maternal IL-4Ra 50 genotypes (P=0.0003) with "Western or Eastern" lifestyles/environments. With the adjustment for multiple comparisons using a false discovery rate (FDR) of 0.05, the interactive effect of the maternal IL-4Ra50 SNP was significant. Conclusion: Maternal genetic variants in IL-4/IL-13 pathway genes, such as IL-13 130 and IL-4Ra50, influenced IgE levels in school children that were independent of the children's genetic effects. These effects differ in "Western or Eastern" environments.

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