Characterisation and optimisation of HIV-1-based SARS-CoV-2 pseudovirus
| dc.contributor.author | Narayan, Maya | |
| dc.contributor.supervisor | Carl Mousley | en_US |
| dc.contributor.supervisor | Padraig Strappe | en_US |
| dc.contributor.supervisor | Brian Brestovac | en_US |
| dc.date.accessioned | 2025-07-31T05:54:06Z | |
| dc.date.available | 2025-07-31T05:54:06Z | |
| dc.date.issued | 2025 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/98199 | |
| dc.description.abstract |
This study successfully generated high-titre HIV-1-based SARS-CoV-2 pseudovirus and characterised key factors influencing its infectivity including SARS-CoV-2 N incorporation. Optimising pseudovirus production and cell models can enhance assay efficiency and reproducibility, establishing a robust platform for SARS-CoV-2 research. These findings are valuable for the study of infectious diseases, serving not only as a model for spike-mediated entry but also as a tool for investigating the function of other structural proteins involved in viral assembly. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Characterisation and optimisation of HIV-1-based SARS-CoV-2 pseudovirus | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | MRes | en_US |
| curtin.department | Curtin Medical School | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |
| curtin.contributor.orcid | Narayan, Maya [0009-0006-8416-4492] | en_US |