Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Protocol of the Australasian Malignant Pleural Effusion-2 (AMPLE-2) trial: A multicentre randomised study of aggressive versus symptom-guided drainage via indwelling pleural catheters

    241783_241783.pdf (827.0Kb)
    Access Status
    Open access
    Authors
    Azzopardi, M.
    Thomas, R.
    Muruganandan, S.
    Lam, D.
    Garske, L.
    Kwan, B.
    Rashid Ali, M.
    Nguyen, P.
    Yap, E.
    Horwood, F.
    Ritchie, A.
    Bint, M.
    Tobin, C.
    Shrestha, R.
    Piccolo, F.
    De Chaneet, C.
    Creaney, J.
    Newton, R.
    Hendrie, Delia
    Murray, K.
    Read, C.
    Feller-Kopman, D.
    Maskell, N.
    Gary Lee, Y.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Azzopardi, M. and Thomas, R. and Muruganandan, S. and Lam, D. and Garske, L. and Kwan, B. and Rashid Ali, M. et al. 2016. Protocol of the Australasian Malignant Pleural Effusion-2 (AMPLE-2) trial: A multicentre randomised study of aggressive versus symptom-guided drainage via indwelling pleural catheters. BMJ Open. 6 (7): pp. e011480.
    Source Title
    BMJ Open
    ISSN
    2044-6055
    School
    Department of Health Policy and Management
    Remarks

    This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by-nc/4.0/

    URI
    http://hdl.handle.net/20.500.11937/9839
    Collection
    • Curtin Research Publications
    Abstract

    Introduction: Malignant pleural effusions (MPEs) can complicate most cancers, causing dyspnoea and impairing quality of life (QoL). Indwelling pleural catheters (IPCs) are a novel management approach allowing ambulatory fluid drainage and are increasingly used as an alternative to pleurodesis. IPC drainage approaches vary greatly between centres. Some advocate aggressive (usually daily) removal of fluid to provide best symptom control and chance of spontaneous pleurodesis. Daily drainages however demand considerably more resources and may increase risks of complications. Others believe that MPE care is palliative and drainage should be performed only when patients become symptomatic (often weekly to monthly). Identifying the best drainage approach will optimise patient care and healthcare resource utilisation. Methods and analysis: A multicentre, open-label randomised trial. Patients with MPE will be randomised 1:1 to daily or symptom-guided drainage regimes after IPC insertion. Patient allocation to groups will be stratified for the cancer type (mesothelioma vs others), performance status (Eastern Cooperative Oncology Group status 0–1 vs ≥2), presence of trapped lung (vs not) and prior pleurodesis (vs not). The primary outcome is the mean daily dyspnoea score, measured by a 100 mm visual analogue scale (VAS) over the first 60 days. Secondary outcomes include benefits on physical activity levels, rate of spontaneous pleurodesis, complications, hospital admission days, healthcare costs and QoL measures. Enrolment of 86 participants will detect a mean difference of VAS score of 14 mm between the treatment arms (5% significance, 90% power) assuming a common between-group SD of 18.9 mm and a 10% lost to follow-up rate.Ethics and dissemination: The Sir Charles Gairdner Group Human Research Ethics Committee has approved the study (number 2015-043). Results will be published in peer-reviewed journals and presented at scientific meetings.

    Related items

    Showing items related by title, author, creator and subject.

    • Protocol of the PLeural Effusion and Symptom Evaluation (PLEASE) study on the pathophysiology of breathlessness in patients with symptomatic pleural effusions
      Thomas, R.; Azzopardi, M.; Muruganandan, S.; Read, C.; Murray, K.; Eastwood, Peter; Jenkins, Susan; Singh, B.; Lee, Y. (2016)
      Introduction: Pleural effusion is a common clinical problem that can complicate many medical conditions. Breathlessness is the most common symptom of pleural effusion of any cause and the most common reason for pleural ...
    • The effects of pleural fluid drainage on respiratory function in mechanically ventilated patients after cardiac surgery
      Brims, Fraser; Davies, M.; Elia, A.; Griffiths, M. (2015)
      BACKGROUND: Pleural effusions occur commonly after cardiac surgery and the effects of drainage on gas exchange in this population are not well established. We examined pulmonary function indices following drainage of ...
    • Physiology of breathlessness associated with pleural effusions
      Thomas, R.; Jenkins, Susan; Eastwood, Peter; Gary Lee, Y.; Singh, B. (2015)
      Purpose of review: Pleural effusions have a major impact on the cardiorespiratory system. This article reviews the pathophysiological effects of pleural effusions and pleural drainage, their relationship with breathlessness, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.