CFD Approach for Non-Ideally Mixed Bioreactor Modeling
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In this paper, we address the progress, challenges and prospect of modeling mixing in bioreactor by the utilization of Computational Fluid Dynamics (CFD). Efficient operation of bioreactor is essential in the biotechnological process, not only to ensure good yield but also to maintain consistent product quality. Process modeling technique has frequently been adopted in the bioreactor design, optimization and control as well as in scale-up process. One of the critical issues in bioreactor modeling is the need to overcome the mass and heat transfer limitations imposed on the bioreactor performance, particularly the close interaction between fluid flow and the biological reactions. CFD can be applied to overcome this obstacles by integrating the flow rates between adjacent zones, and fluid mechanical quantities, as the integration of mixing phenomena into the bioreactor modeling is considered a vital aspect in the efficient design and scale-up of bioreactor system.
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Liew, Emily Wan Teng (2011)Mixing plays a substantial role in determining the overall performance of a bioreactor. Well mixing in bioreactor, especially for ethanolic fermentation process is important for the homogenization of miscible and immiscible ...
Liew, Emily; Nandong, Jobrun; Samyudia, Yudi (2008)In this paper, we address the progress, challenges and prospect of modeling of mixing in bioreactor. We aim to briefly review the progress in the integration of the mixing behaviors into bioreactor modeling and simulation ...
Liew, Emily; Law, Ming (2012)Computational fluid dynamics (CFD) is a handy tool in the study of mixing problems in bioreactor dealing with ethanolic fermentation process. Due to the complexity of the bioreactor performance which involves microbial ...