Platelet Receptor Shedding
MetadataShow full item record
Receptor shedding is a mechanism for irreversible removal of transmembrane cell surf.1ce receptors by proteolysis of the receptor at a position near the extracellular surface of the plasma membrane. This process generates a soluble ectodomain fragment and a membrane-associated remnant fragment, and is distinct from loss of receptor surface expression by internalization or microparticle release or secretion of alternatively spliced soluble forms of receptors lacking a transmembrane domain. There has been an increased focus on new methods for analyzing shedding of platelet glycoprotein (GP)Ib-IX-V and GPVI because these receptors are platelet specific and are critical for the initiation of platelet adhesion and activation in thrombus formation at arterial shear rates. Platelet receptor shedding provides a mechanism for downregulating surface expression resulting in loss of ligand binding, decreasing the surface density affecting receptor cross linking and signalling and generation of proteolytic fragments that may be functional and/ or provide platelet-specific biomarkers.
Showing items related by title, author, creator and subject.
Specific inhibition of ectodomain shedding of glycoprotein lba by targeting its juxtamembrane shedding cleavage siteLiang, X; Russell, S; Estelle, S; Jones, L; Cho, S; Khan, M; Berndt, Michael; Bunting, S; Ware, J; Li, R (2013)Background: Ectodomain shedding of glycoprotein Ibα (GPIbα), a proteolytic event in which metalloprotease ADAM17 cleaves the Gly464-Val465 bond and releases glycocalicin to the plasma, is considered a critical step in ...
Deng, W.; Xu, Y.; Chen, W.; Paul, D.; Syed, A.; Dragovich, M.; Liang, X.; Zakas, P.; Berndt, Michael; Di Paola, J.; Ware, J.; Lanza, F.; Doering, C.; Bergmeier, W.; Zhang, X.; Li, R. (2016)Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable ...
Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of type 1 diabetesArthur, J.; Shen, Y.; Chen, Younan; Qiao, J.; Ni, R.; Lu, Y.; Andrews, R.; Gardiner, E.; Cheng, J. (2013)Thrombosis is a life-threatening complication of diabetes. Platelet reactivity is crucial to thrombus formation, particularly in arterial vessels and in thrombotic complications causing myocardial infarction or ischaemic ...