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dc.contributor.authorGardiner, E.
dc.contributor.authorAl-Tamimi, M.
dc.contributor.authorRobert, A.
dc.contributor.authorBerndt, Michael
dc.contributor.editorJonathan M Gibbins, Martyn P. Mahaut-Smith
dc.date.accessioned2017-01-30T11:19:09Z
dc.date.available2017-01-30T11:19:09Z
dc.date.created2013-04-01T20:00:46Z
dc.date.issued2012
dc.identifier.citationGardiner, Elizabeth E. and Al-Tamimi, Mohammad and Andrews, Robert K. and Berndt, Michael C. 2012. Platelet Receptor Shedding, in Gibbins, J.M. and Mahaut-Smith, M.P. (ed), Platelets and Megakaryocytes: Additional protocols and perspectives, Vol. 3, pp. 321-339. New York: Springer.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/10489
dc.identifier.doi10.1007/978-1-61779-307-3_22
dc.description.abstract

Receptor shedding is a mechanism for irreversible removal of transmembrane cell surf.1ce receptors by proteolysis of the receptor at a position near the extracellular surface of the plasma membrane. This process generates a soluble ectodomain fragment and a membrane-associated remnant fragment, and is distinct from loss of receptor surface expression by internalization or microparticle release or secretion of alternatively spliced soluble forms of receptors lacking a transmembrane domain. There has been an increased focus on new methods for analyzing shedding of platelet glycoprotein (GP)Ib-IX-V and GPVI because these receptors are platelet specific and are critical for the initiation of platelet adhesion and activation in thrombus formation at arterial shear rates. Platelet receptor shedding provides a mechanism for downregulating surface expression resulting in loss of ligand binding, decreasing the surface density affecting receptor cross linking and signalling and generation of proteolytic fragments that may be functional and/ or provide platelet-specific biomarkers.

dc.publisherSpringer
dc.subjectGPib-IX-V
dc.subjectADAMI 0
dc.subjectGPVI
dc.subjectReceptors
dc.subjectPlatelets
dc.subjectADAMI7
dc.subjectSheddases
dc.titlePlatelet Receptor Shedding
dc.typeBook Chapter
dcterms.source.startPage321
dcterms.source.endPage339
dcterms.source.titlePlatelets and Megakaryocytes
dcterms.source.isbn978-1-61779-306-6
dcterms.source.isbn9781617793073
dcterms.source.placeUK
dcterms.source.chapter22
curtin.department
curtin.accessStatusFulltext not available


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