Development of natural gum based glipizide mucoadhesive microsphere
MetadataShow full item record
The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among six formulations, microspheres of four formulations (F1-F4) were discrete, spherical and free flowing. There was an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing microspheres while a forward relationship was found between amount of gum and surface smoothness in case of the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural gum based glipizide mucoadhesive microsphere.
This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by-nc-sa/3.0/. Please refer to the licence to obtain terms for any further reuse or distribution of this work.
Showing items related by title, author, creator and subject.
Monodisperse Ca 0.15Fe 2.85O 4 microspheres: Facile preparation, characterization, and optical propertiesShen, Y.; Zhao, Q.; Li, Xin Yong; Zhang, D. (2012)Micro/nanospheres have been intensively investigated recently because of their attractive applications. While long reaction times, harsh reaction conditions or multiple steps are generally required for the effective ...
Wang, J.; Zhou, Y.; Hu, Y.; O'hayre, R.; Shao, Zongping (2011)TiO2 mesoporous nanocrystalline microspheres assembled from uniform nanoparticles were synthesized by a facile and template-free hydrolytic precipitation route in normal solvent media. The phase structure, morphology, and ...
Ding, Ailin; Yang, L.; Fan, S.; Lou, Xia (2013)Methane gas hydrates are a promising alternative for storage and transport of natural gas. In this paper, porous poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(2-hydroxyethyl methacrylate-co-methacrylic acid) ...