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Development of natural gum based glipizide mucoadhesive microsphere

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Open access
Authors
Al Mamun, A.
Bagchi, M.
Amin, L.
Sutradhar, K.
Huda, Naz
Date
2014
Type
Journal Article

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Al Mamun, Md. Abdur Rouf and Bagchi, Monisha and Amin, Md. Lutful and Sutradhar, Kumar Bishwajit and Huda, Naz Hasan. 2014. Development of natural gum based glipizide mucoadhesive microsphere. Journal of Applied Pharmaceutical Science. 4 (1): pp. 066-069.
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Journal of Applied Pharmaceutical Science
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This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by-nc-sa/3.0/. Please refer to the licence to obtain terms for any further reuse or distribution of this work.

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Abstract

The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among six formulations, microspheres of four formulations (F1-F4) were discrete, spherical and free flowing. There was an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing microspheres while a forward relationship was found between amount of gum and surface smoothness in case of the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural gum based glipizide mucoadhesive microsphere.