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dc.contributor.authorAl Mamun, A.
dc.contributor.authorBagchi, M.
dc.contributor.authorAmin, L.
dc.contributor.authorSutradhar, K.
dc.contributor.authorHuda, Naz
dc.identifier.citationAl Mamun, Md. Abdur Rouf and Bagchi, Monisha and Amin, Md. Lutful and Sutradhar, Kumar Bishwajit and Huda, Naz Hasan. 2014. Development of natural gum based glipizide mucoadhesive microsphere. Journal of Applied Pharmaceutical Science. 4 (1): pp. 066-069.

The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among six formulations, microspheres of four formulations (F1-F4) were discrete, spherical and free flowing. There was an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing microspheres while a forward relationship was found between amount of gum and surface smoothness in case of the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural gum based glipizide mucoadhesive microsphere.

dc.publisherMedipoeia Publication
dc.subjectxanthan gum
dc.subjectionic gelation method
dc.subjectguar gum
dc.subjectmucoadhesive microsphere
dc.titleDevelopment of natural gum based glipizide mucoadhesive microsphere
dc.typeJournal Article
dcterms.source.titleJournal of Applied Pharmaceutical Science

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curtin.accessStatusOpen access

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