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    Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients

    240496_240496.pdf (384.8Kb)
    Access Status
    Open access
    Authors
    Goullee, H.
    Wadley, A.
    Cherry, C.
    Allcock, R.
    Black, M.
    Kamerman, P.
    Price, Patricia
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Goullee, H. and Wadley, A. and Cherry, C. and Allcock, R. and Black, M. and Kamerman, P. and Price, P. 2016. Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. Journal of NeuroVirology. 22 (4): pp. 508-517.
    Source Title
    Journal of NeuroVirology
    DOI
    10.1007/s13365-015-0421-4
    ISSN
    1355-0284
    School
    School of Biomedical Sciences
    Remarks

    The final publication is available at Springer via http://doi.org/10.1007/s13365-015-0421-4

    URI
    http://hdl.handle.net/20.500.11937/10666
    Collection
    • Curtin Research Publications
    Abstract

    HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV+ black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p < 0.0001; R2 = 0.19) or haplotypes (model p < 0.0001; R2 = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study.

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