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    TNF Block Gene Variants Associated with Pain Intensity in Black Southern Africans with HIV-associated Sensory Neuropathy

    Access Status
    Fulltext not available
    Authors
    Hendry, L.
    Wadley, A.
    Cherry, C.
    Price, Patricia
    Lombard, Z.
    Kamerman, P.
    Date
    2016
    Type
    Journal Article
    
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    Citation
    Hendry, L. and Wadley, A. and Cherry, C. and Price, P. and Lombard, Z. and Kamerman, P. 2016. TNF Block Gene Variants Associated with Pain Intensity in Black Southern Africans with HIV-associated Sensory Neuropathy. Clinical Journal of Pain. 32 (1): pp. 45-50.
    Source Title
    Clinical Journal of Pain
    DOI
    10.1097/AJP.0000000000000224
    ISSN
    0749-8047
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/73058
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: HIV-associated sensory neuropathy (HIV-SN) is a common neurological complication of HIV infection, and often is painful. Tumour necrosis factor (TNF)-[alpha] is implicated in neuropathic pain, but associations between neuropathic pain and polymorphisms in the TNFA gene have not been identified. The "TNF block" is a region of high linkage disequilibrium within the central major histocompatability complex that contains several genes involved in the regulation of inflammation, including TNFA. Polymorphisms in the block have been associated with altered risk of HIV-SN, but no investigations into whether this region is associated with the painful symptoms of neuropathy have been undertaken. Therefore, we investigated whether polymorphisms in the TNF block are associated with pain intensity in black Southern Africans with HIV-SN. Methods: Single nucleotide polymorphisms (SNPs) defining TNF block haplotypes and African-specific tagSNPs were genotyped in samples from 150 black Southern Africans with HIV-SN. Results: One SNP allele, rs28445017*A, was significantly associated with increased pain intensity after correction for age, sex and CD4 T-cell count. A common 3-SNP haplotype containing rs28445017*G remained associated with reduced pain intensity after correction for covariates and multiple comparisons. Discussion: We identified a novel genetic associations between polymorphisms in the TNF block and pain intensity in black Southern Africans with HIV-SN. Our study implicates rs28445017 in painful HIV-SN, although its precise role and whether it may be causative is unclear. rs28445017 was not associated with risk for HIV-SN as such, highlighting potential differences between the pathophysiology of the neuropathy and the painful features of the neuropathy. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

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