STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study
|dc.identifier.citation||Fenstad, M. and Johnson, M. and Løset, M. and Mundal, S. and Roten, L. and Eide, I. and Bjørge, L. et al. 2010. STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study. Molecular Human Reproduction. 16 (12): pp. 960-968.|
Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.
|dc.title||STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study|
|dcterms.source.title||Molecular Human Reproduction|
|curtin.department||School of Biomedical Sciences|
|curtin.accessStatus||Open access via publisher|
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