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    Growth hormone and physical exercise: Current considerations

    Access Status
    Open access via publisher
    Authors
    Cruzat, Vinicius
    Donato, J.
    Tirapegui, J.
    Schneider, C.
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Cruzat, V. and Donato, J. and Tirapegui, J. and Schneider, C. 2008. Growth hormone and physical exercise: Current considerations. Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences. 44 (4): pp. 549-562.
    Source Title
    Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences
    DOI
    10.1590/S1516-93322008000400003
    ISSN
    1516-9332
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/11079
    Collection
    • Curtin Research Publications
    Abstract

    Although growth hormone (GH) is one of the most extensively studied hormones, various aspects related to this hormone have not been completely established, including its relationship with physical exercise. Recent studies have contributed to the understanding of the mechanisms of action of GH, which can be divided into 1) direct actions mediated by intracellular signals that are triggered by the binding of GH to its receptor on the plasma membrane, and 2) indirect actions mediated mainly by the regulation of the synthesis of insulin-like growth factors (IGF). Physical exercise has been shown to be a potent stimulator of GH release, especially in young men and women. The magnitude of this increase is influenced by several factors, especially the intensity and volume of exercise, in addition to training status. In this respect, athletes normally present a lower exercise-induced GH release than sedentary or poorly trained individuals. Experimental evidence indicates that GH may 1) favor the mobilization of free fatty acids from adipose tissue for energy generation, 2) increase the capacity of fat oxidation, and 3) increase energy expenditure.

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