Therapeutic antibodies: Discovery, design and deployment
Abstract
Therapeutic antibodies have come of age with major progress being made in cancer, autoimmunity and chronic inflammation, as well as a wide range of other human diseases. Antibody engineering is further driving development of novel antibody formats and genetically modified cell-based therapies that harness the power of the immune system to progress cures in otherwise intractable human diseases. Nevertheless, there are still significant challenges ahead for basic and applied research relating to therapeutic antibodies. This special issue of the journal provides reviews and opinions that relate to the discovery, design and deployment of antibodies as therapeutics.
Citation
Ramsland, P. and Hutchinson, A. and Carter, P. 2015. Therapeutic antibodies: Discovery, design and deployment. Molecular Immunology. 67 (2, Part A): pp. 1-3.
Source Title
Molecular Immunology
ISSN
School
School of Biomedical Sciences
Collection
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Ramsland, Paul; Hutchinson, A.; Carter, P. (2015)© 2015 Elsevier Ltd. Therapeutic antibodies have come of age with major progress being made in cancer, autoimmunity and chronic inflammation, as well as a wide range of other human diseases. Antibody engineering is further ...
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Dingjan, T.; Spendlove, I.; Durrant, L.; Scott, A.; Yuriev, E.; Ramsland, Paul (2015)© 2015 Elsevier Ltd. Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability ...