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    Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness

    Access Status
    Fulltext not available
    Authors
    Slater, Helen
    Arendt-Nielsen, Lars
    Wright, Tony
    Graven-Nielsen, Thomas
    Date
    2005
    Type
    Journal Article
    
    Metadata
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    Citation
    Slater, Helen and Arendt-Nielsen, Lars and Wright, Antony and Graven-Nielsen, Thomas. 2005. Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness. Pain. 114 (1-2): 118-130.
    Source Title
    Pain
    DOI
    10.1016/j.pain.2004.12.003
    Faculty
    School of Physiotherapy
    Division of Health Sciences
    School
    Center for Sensory-Motor Interaction, Aalborg University, Denmark
    URI
    http://hdl.handle.net/20.500.11937/11383
    Collection
    • Curtin Research Publications
    Abstract

    This study compares the effect of experimental muscle pain on deep tissue sensitivity and force attenuation in the wrist extensors of patients with lateral epicondylalgia (n=20), and healthy controls (n=20) with experimentally induced sensori-motor characteristics simulating lateral epicondylalgia. Delayed onset muscle soreness (DOMS) in wrist extensors of healthy controls was induced by eccentric exercise in one arm 24 h prior to injection (Day 0). Saline-induced pain intensity (visual analogue scale, VAS), distribution, and quality were assessed quantitatively in both arms for both groups. Pressure pain thresholds (PPT) were assessed at three different sites in the wrist extensors. Maximal grip force and wrist extension force were recorded. In response to saline-induced pain in the extensor carpi radialis brevis, regardless of arm, the patient group demonstrated a significantly quicker pain onset (P<0.01), mapped larger pain areas and more referred pain areas, compared to healthy controls (P<0.03). Pain persisted significantly longer in the sore arm of the patient group, compared with all other arms (P<0.02). Patients demonstrated significant bilateral hyperalgesia at extensor carpi radialis brevis during and post saline-induced pain compared to pre-injection and healthy controls (P<0.04). The sore arm in patients and the DOMS arms in healthy subjects showed significantly reduced maximal force (P<0.0001), at all Day 1 times compared with the control arms. In patients, the bilateral increase in deep tissue sensitivity and enlarged referred pain areas during saline-induced pain might suggest involvement of central sensitisation.

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    • Experimental deep tissue pain in wrist extensors--a model of lateral epicondylalgia
      Slater, Helen; Arendt-Nielsen, Lars; Wright, Tony (2003)
      The aim of this experimental study was to develop an in vivo model demonstrating sensory and motor interactions comparable to those seen in patients presenting with lateral epicondylalgia (i.e., deep tissue pain and ...
    • Effects of a manual therapy technique in experimental lateral epicondylalgia
      Slater, Helen; Arendt-Nielsen, Lars; Wright, Tony; Graven-Nielsen, Thomas (2005)
      In patients with lateral epicondylalgia, mobilization-with-movement (MWM) is used as an intervention aimed at achieving analgesia and enhancing grip force, although the mechanisms underlying these effects are unclear. The ...
    • Low-Dose Sublingual Ketamine Does Not Modulate Experimentally Induced Mechanical Hyperalgesia in Healthy Subjects
      Slater, Helen; Graven-Neilsen, T.; Wright, Anthony; Schug, S. (2012)
      Objective: Musculoskeletal pain has been associated with N-methyl-d-aspartate (NMDA) receptor-mediated mechanisms. This randomized controlled trial (RCT) investigated the effect of the NMDA receptor antagonist ketamine ...
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