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dc.contributor.authorHales, B.
dc.contributor.authorMartin, A.
dc.contributor.authorPearce, L.
dc.contributor.authorRueter, K.
dc.contributor.authorZhang, Guicheng
dc.contributor.authorKhoo, S.
dc.contributor.authorHayden, C.
dc.contributor.authorBizzintino, J.
dc.contributor.authorMcMinn, P.
dc.contributor.authorGeelhoed, G.
dc.contributor.authorLee, W.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorLaing, I.
dc.contributor.authorLesouëf, P.
dc.contributor.authorThomas, W.
dc.date.accessioned2017-01-30T11:24:53Z
dc.date.available2017-01-30T11:24:53Z
dc.date.created2016-09-12T08:36:29Z
dc.date.issued2009
dc.identifier.citationHales, B. and Martin, A. and Pearce, L. and Rueter, K. and Zhang, G. and Khoo, S. and Hayden, C. et al. 2009. Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation. Clinical and Experimental Allergy. 39 (8): pp. 1170-1178.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/11456
dc.identifier.doi10.1111/j.1365-2222.2009.03252.x
dc.description.abstract

Background Atopic sensitization to the house dust mite (HDM) is associated with altered antibody responses to the nasopharyngeal colonizing bacterium Haemophilus influenzae and children admitted to the emergency department for asthma exacerbation have reduced IgG responses to HDM allergens. Objective To investigate anti-bacterial and anti-allergen antibody responses during convalescence from asthma exacerbation and differences found in exacerbations associated with and without viral infection. Results IgE antibodies to the P6 bacterial antigen increased in 60% of sera during convalescence and for many children achieved titres as high as IgE titres to allergens. In contrast IgE anti-HDM titres declined during convalescence. The anti-bacterial IgE titres were the same in subjects with and without virus infection while the anti-HDM IgE declined more rapidly in virus-infected subjects. IgG titres to the major HDM allergens showed no consistent increase and the overall IgG anti-HDM titres even declined in subjects without a virus infection. Anti-bacterial IgG antibodies in contrast to IgE did not change. Patients with frequent episodic or persistent asthma had similar IgE anti-bacterial titres to patients with infrequent asthma during the acute phase, although they had reduced IgG titres to both the bacteria and the HDM. Conclusions During the period following an acute exacerbation of asthma there was a marked and specific increase in anti-bacterial IgE compared with a reduced IgE response to HDM. This provides further support for the concept of T-helper type 2 responses to bacterial antigens playing a role in asthma pathogenesis. © 2009 Blackwell Publishing Ltd.

dc.publisherBlackwell Science Ltd
dc.titleAnti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation
dc.typeJournal Article
dcterms.source.volume39
dcterms.source.number8
dcterms.source.startPage1170
dcterms.source.endPage1178
dcterms.source.issn0954-7894
dcterms.source.titleClinical and Experimental Allergy
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


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