Long-term outcomes of the western australian trial of screening for abdominal aortic aneurysms: Secondary analysis of a randomized clinical trial
MetadataShow full item record
Importance: Mortality from ruptured abdominal aortic aneurysms (AAAs) remains high. The benefit of screening older men for AAAs needs to be assessed in a range of health care settings. Objective: To assess the influence of screening for AAAs in men aged 64 to 83 years on mortality from AAAs. Design, Setting, and Participants: This randomized clinical trial performed from April 1, 1996, through March 31, 1999, with a mean of 12.8 years of follow-up (range, 11.6-14.2 years) included a population-based sample from a single metropolitan region in Western Australia identified via the electoral roll. Data analysis was performed from June 1, 2015, to June 1, 2016. Interventions: Randomization to an invitation to undergo ultrasonography of the abdominal aorta or a control group without invitation. Main Outcomes and Measures: Surgery for and mortality from AAA. Results: A total of 49 801 men aged 64 to 83 years were identified for the study. Men living too far from screening centers (n = 8671) or who died before invitation (n = 2650) were excluded, resulting in 19 249 men in the invited group and 19 231 controls (mean [SD] age, 72.5 [4.6] years; 95% white). Of 19 249 men invited for screening, 12 203 (63.4%) attended. There were more elective operations (536 vs 414, P < .001) and fewer ruptured AAAs (72 vs 99, P = .04) in the invited group compared with the control group. Overall, there were 90 deaths from AAAs in the invited group (mortality rate, 47.86 per 100 000 person-years; 95% CI, 38.93-58.84) and 98 in the control group (52.53 per 100 000 person-years; 95% CI, 43.09-64.03) for a rate ratio of 0.91 (95% CI, 0.68-1.21). For men aged 65 to 74 years, the AAA mortality rate in the invited group was 34.52 per 100 000 person-years (95% CI, 26.02-45.81) compared with 37.67 per 100 000 person-years (95% CI, 28.71-49.44) in the control group for a rate ratio of 0.92 (95% CI, 0.62-1.36). The number needed to invite for screening to prevent 1 death from an AAA in 5 years was 4784 for men aged 64 to 83 years and 3290 for men aged 65 to 74 years. There were no meaningful differences in all-cause, cardiovascular, and other mortality risks. Conclusions and Relevance: Use of the electoral roll to identify and invite men aged 64 to 83 years for screening for AAAs had no significant effect on the overall mortality from AAAs.
Showing items related by title, author, creator and subject.
Increased mortality among Indigenous persons during and after release from prison in New South WalesKariminia, A.; Butler, Tony; Jones, J.; Law, M. (2012)Objective: To estimate the overall and cause specific mortality of Aboriginal offenders in New South Wales (NSW), Australia. Methods: The study cohort consisted of all Aboriginal men and women aged 18 years and older who ...
Beatty, Shelley Ellen (2003)The long-term regular use of tobacco and hazardous alcohol use are responsible for significant mortality and morbidity as well as social and economic harm in Australia each year. There is necessary the more cost-efficient ...
Self-injury Mortality in the United States in the Early 21st Century: A Comparison With Proximally Ranked DiseasesRockett, I.; Lilly, C.; Jia, H.; Larkin, G.; Miller, Ted; Nelson, L.; Nolte, K.; Putnam, S.; Smith, G.; Caine, E. (2016)Importance: Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths ...