Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Law, M.; Bishop, D.; Lee, J.; Brossard, M.; Martin, N.; Moses, Eric; Song, F.; Barrett, J.; Kumar, R.; Easton, D.; Pharoah, P.; Swerdlow, A.; Kypreou, K.; Taylor, J.; Harland, M.; Randerson-Moor, J.; Akslen, L.; Andresen, P.; Avril, M.; Azizi, E.; Scarrà, G.; Brown, K.; Debniak, T.; Duffy, D.; Elder, D.; Fang, S.; Friedman, E.; Galan, P.; Ghiorzo, P.; Gillanders, E.; Goldstein, A.; Gruis, N.; Hansson, J.; Helsing, P.; Hocevar, M.; Höiom, V.; Ingvar, C.; Kanetsky, P.; Chen, W.; Landi, M.; Lang, J.; Lathrop, G.; Lubinski, J.; MacKie, R.; Mann, G.; Molven, A.; Montgomery, G.; Novakovic, S.; Olsson, H.; Puig, S.; Puig-Butille, J.; Qureshi, A.; Radford-Smith, G.; Van Der Stoep, N.; Van Doorn, R.; Whiteman, D.; Craig, J.; Schadendorf, D.; Simms, L.; Burdon, K.; Nyholt, D.; Pooley, K.; Orr, N.; Stratigos, A.; Cust, A.; Ward, S.; Hayward, N.; Han, J.; Schulze, H.; Dunning, A.; Bishop, J.; Demenais, F.; Amos, C.; MacGregor, S.; Iles, M.

doi:10.1038/ng.3373

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Authors

Law, M.

Bishop, D.

Lee, J.

Brossard, M.

Martin, N.

Moses, Eric

Song, F.

Barrett, J.

Kumar, R.

Easton, D.

Pharoah, P.

Swerdlow, A.

Kypreou, K.

Taylor, J.

Harland, M.

Randerson-Moor, J.

Akslen, L.

Andresen, P.

Avril, M.

Azizi, E.

Scarrà, G.

Brown, K.

Debniak, T.

Duffy, D.

Elder, D.

Fang, S.

Friedman, E.

Galan, P.

Ghiorzo, P.

Gillanders, E.

Goldstein, A.

Gruis, N.

Hansson, J.

Helsing, P.

Hocevar, M.

Höiom, V.

Ingvar, C.

Kanetsky, P.

Chen, W.

Landi, M.

Lang, J.

Lathrop, G.

Lubinski, J.

MacKie, R.

Mann, G.

Molven, A.

Montgomery, G.

Novakovic, S.

Olsson, H.

Puig, S.

Puig-Butille, J.

Qureshi, A.

Radford-Smith, G.

Van Der Stoep, N.

Van Doorn, R.

Whiteman, D.

Craig, J.

Schadendorf, D.

Simms, L.

Burdon, K.

Nyholt, D.

Pooley, K.

Orr, N.

Stratigos, A.

Cust, A.

Ward, S.

Hayward, N.

Han, J.

Schulze, H.

Dunning, A.

Bishop, J.

Demenais, F.

Amos, C.

MacGregor, S.

Iles, M.

Date

2015

Type

Journal Article

Metadata

Show full item record

Citation

Law, M. and Bishop, D. and Lee, J. and Brossard, M. and Martin, N. and Moses, E. and Song, F. et al. 2015. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics. 47 (9): pp. 987-995.

Source Title

Nature Genetics

DOI

10.1038/ng.3373

ISSN

1061-4036

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/11908

Collection

Curtin Research Publications

Abstract

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.