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dc.contributor.authorLaw, M.
dc.contributor.authorBishop, D.
dc.contributor.authorLee, J.
dc.contributor.authorBrossard, M.
dc.contributor.authorMartin, N.
dc.contributor.authorMoses, Eric
dc.contributor.authorSong, F.
dc.contributor.authorBarrett, J.
dc.contributor.authorKumar, R.
dc.contributor.authorEaston, D.
dc.contributor.authorPharoah, P.
dc.contributor.authorSwerdlow, A.
dc.contributor.authorKypreou, K.
dc.contributor.authorTaylor, J.
dc.contributor.authorHarland, M.
dc.contributor.authorRanderson-Moor, J.
dc.contributor.authorAkslen, L.
dc.contributor.authorAndresen, P.
dc.contributor.authorAvril, M.
dc.contributor.authorAzizi, E.
dc.contributor.authorScarrà, G.
dc.contributor.authorBrown, K.
dc.contributor.authorDebniak, T.
dc.contributor.authorDuffy, D.
dc.contributor.authorElder, D.
dc.contributor.authorFang, S.
dc.contributor.authorFriedman, E.
dc.contributor.authorGalan, P.
dc.contributor.authorGhiorzo, P.
dc.contributor.authorGillanders, E.
dc.contributor.authorGoldstein, A.
dc.contributor.authorGruis, N.
dc.contributor.authorHansson, J.
dc.contributor.authorHelsing, P.
dc.contributor.authorHocevar, M.
dc.contributor.authorHöiom, V.
dc.contributor.authorIngvar, C.
dc.contributor.authorKanetsky, P.
dc.contributor.authorChen, W.
dc.contributor.authorLandi, M.
dc.contributor.authorLang, J.
dc.contributor.authorLathrop, G.
dc.contributor.authorLubinski, J.
dc.contributor.authorMacKie, R.
dc.contributor.authorMann, G.
dc.contributor.authorMolven, A.
dc.contributor.authorMontgomery, G.
dc.contributor.authorNovakovic, S.
dc.contributor.authorOlsson, H.
dc.contributor.authorPuig, S.
dc.contributor.authorPuig-Butille, J.
dc.contributor.authorQureshi, A.
dc.contributor.authorRadford-Smith, G.
dc.contributor.authorVan Der Stoep, N.
dc.contributor.authorVan Doorn, R.
dc.contributor.authorWhiteman, D.
dc.contributor.authorCraig, J.
dc.contributor.authorSchadendorf, D.
dc.contributor.authorSimms, L.
dc.contributor.authorBurdon, K.
dc.contributor.authorNyholt, D.
dc.contributor.authorPooley, K.
dc.contributor.authorOrr, N.
dc.contributor.authorStratigos, A.
dc.contributor.authorCust, A.
dc.contributor.authorWard, S.
dc.contributor.authorHayward, N.
dc.contributor.authorHan, J.
dc.contributor.authorSchulze, H.
dc.contributor.authorDunning, A.
dc.contributor.authorBishop, J.
dc.contributor.authorDemenais, F.
dc.contributor.authorAmos, C.
dc.contributor.authorMacGregor, S.
dc.contributor.authorIles, M.
dc.date.accessioned2017-01-30T11:27:33Z
dc.date.available2017-01-30T11:27:33Z
dc.date.created2016-01-20T20:00:36Z
dc.date.issued2015
dc.identifier.citationLaw, M. and Bishop, D. and Lee, J. and Brossard, M. and Martin, N. and Moses, E. and Song, F. et al. 2015. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics. 47 (9): pp. 987-995.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/11908
dc.identifier.doi10.1038/ng.3373
dc.description.abstract

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.

dc.titleGenome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
dc.typeJournal Article
dcterms.source.volume47
dcterms.source.number9
dcterms.source.startPage987
dcterms.source.endPage995
dcterms.source.issn1061-4036
dcterms.source.titleNature Genetics
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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