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    Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet

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    Authors
    Li Kwok Cheong, J.
    Croft, K.
    Henry, P.
    Matthews, V.
    Hodgson, J.
    Ward, Natalie
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Li Kwok Cheong, J. and Croft, K. and Henry, P. and Matthews, V. and Hodgson, J. and Ward, N. 2014. Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Archives of Biochemistry and Biophysics. 559: pp. 46-52.
    Source Title
    Archives of Biochemistry and Biophysics
    DOI
    10.1016/j.abb.2014.02.005
    ISSN
    0003-9861
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/12389
    Collection
    • Curtin Research Publications
    Abstract

    We have investigated the effects of the major polyphenol in coffee, chlorogenic acid (CGA), on obesity, glucose intolerance, insulin resistance, systemic oxidative stress and endothelial dysfunction in a mouse model of the metabolic syndrome. Thirty C57BL6 mice were randomly divided into (n = 10/group) (i) normal diet (ND), (ii) high fat diet (HFD), or (iii) high fat diet supplemented with 0.5% w/w green coffee bean extract (GCE) rich in chlorogenic acid (HFD + GCE). The high fat diet consisted of 28% fat and all animals were maintained on their diets for 12 weeks. The mice fed a HFD and HFD + GCE displayed symptoms of the metabolic syndrome compared to their normal fed counterparts, although no endothelial dysfunction was detected in the abdominal aortas after 12 weeks. GCE did not attenuate HFD-induced obesity, glucose intolerance, insulin resistance or systemic oxidative stress. Furthermore, GCE did not protect against ex vivo oxidant (hypochlorous acid)-induced endothelial dysfunction.

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