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dc.contributor.authorLi Kwok Cheong, J.
dc.contributor.authorCroft, K.
dc.contributor.authorHenry, P.
dc.contributor.authorMatthews, V.
dc.contributor.authorHodgson, J.
dc.contributor.authorWard, Natalie
dc.date.accessioned2017-01-30T11:30:28Z
dc.date.available2017-01-30T11:30:28Z
dc.date.created2016-01-19T20:00:32Z
dc.date.issued2014
dc.identifier.citationLi Kwok Cheong, J. and Croft, K. and Henry, P. and Matthews, V. and Hodgson, J. and Ward, N. 2014. Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Archives of Biochemistry and Biophysics. 559: pp. 46-52.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/12389
dc.identifier.doi10.1016/j.abb.2014.02.005
dc.description.abstract

We have investigated the effects of the major polyphenol in coffee, chlorogenic acid (CGA), on obesity, glucose intolerance, insulin resistance, systemic oxidative stress and endothelial dysfunction in a mouse model of the metabolic syndrome. Thirty C57BL6 mice were randomly divided into (n = 10/group) (i) normal diet (ND), (ii) high fat diet (HFD), or (iii) high fat diet supplemented with 0.5% w/w green coffee bean extract (GCE) rich in chlorogenic acid (HFD + GCE). The high fat diet consisted of 28% fat and all animals were maintained on their diets for 12 weeks. The mice fed a HFD and HFD + GCE displayed symptoms of the metabolic syndrome compared to their normal fed counterparts, although no endothelial dysfunction was detected in the abdominal aortas after 12 weeks. GCE did not attenuate HFD-induced obesity, glucose intolerance, insulin resistance or systemic oxidative stress. Furthermore, GCE did not protect against ex vivo oxidant (hypochlorous acid)-induced endothelial dysfunction.

dc.titleGreen coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet
dc.typeJournal Article
dcterms.source.volume559
dcterms.source.startPage46
dcterms.source.endPage52
dcterms.source.issn0003-9861
dcterms.source.titleArchives of Biochemistry and Biophysics
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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