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    The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia

    Access Status
    Open access via publisher
    Authors
    Pemberton, L.
    Stone, E.
    Price, Patricia
    Van Bockxmeer, F.
    Brew, B.
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Pemberton, L. and Stone, E. and Price, P. and Van Bockxmeer, F. and Brew, B. 2008. The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia. HIV Medicine. 9 (8): pp. 677-680.
    Source Title
    HIV Medicine
    DOI
    10.1111/j.1468-1293.2008.00614.x
    ISSN
    1464-2662
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/12464
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-a, interleukin (IL)-1a, IL-1ß, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage =1 and CD4 counts of <500 cells/µL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC. © 2008 British HIV Association.

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