The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia
dc.contributor.author | Pemberton, L. | |
dc.contributor.author | Stone, E. | |
dc.contributor.author | Price, Patricia | |
dc.contributor.author | Van Bockxmeer, F. | |
dc.contributor.author | Brew, B. | |
dc.date.accessioned | 2017-01-30T11:30:56Z | |
dc.date.available | 2017-01-30T11:30:56Z | |
dc.date.created | 2016-09-12T08:36:57Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Pemberton, L. and Stone, E. and Price, P. and Van Bockxmeer, F. and Brew, B. 2008. The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia. HIV Medicine. 9 (8): pp. 677-680. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/12464 | |
dc.identifier.doi | 10.1111/j.1468-1293.2008.00614.x | |
dc.description.abstract |
Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-a, interleukin (IL)-1a, IL-1ß, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage =1 and CD4 counts of <500 cells/µL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC. © 2008 British HIV Association. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.title | The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia | |
dc.type | Journal Article | |
dcterms.source.volume | 9 | |
dcterms.source.number | 8 | |
dcterms.source.startPage | 677 | |
dcterms.source.endPage | 680 | |
dcterms.source.issn | 1464-2662 | |
dcterms.source.title | HIV Medicine | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Open access via publisher |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |