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dc.contributor.authorPemberton, L.
dc.contributor.authorStone, E.
dc.contributor.authorPrice, Patricia
dc.contributor.authorVan Bockxmeer, F.
dc.contributor.authorBrew, B.
dc.identifier.citationPemberton, L. and Stone, E. and Price, P. and Van Bockxmeer, F. and Brew, B. 2008. The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia. HIV Medicine. 9 (8): pp. 677-680.

Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-a, interleukin (IL)-1a, IL-1ß, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage =1 and CD4 counts of <500 cells/µL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC. © 2008 British HIV Association.

dc.publisherBlackwell Publishing Ltd
dc.titleThe relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia
dc.typeJournal Article
dcterms.source.titleHIV Medicine
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher

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