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    Release of Bioactive Molecules Using Metal Complexes

    Access Status
    Fulltext not available
    Authors
    Simpson, Peter
    Schatzschneider, U.
    Date
    2014
    Type
    Book Chapter
    
    Metadata
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    Citation
    Simpson, P. and Schatzschneider, U. 2014. Release of Bioactive Molecules Using Metal Complexes, in Gasser, G. (ed), Inorganic Chemical Biology: Principles, Techniques and Applications, pp. 309-339. Chichester: John Wiley & Sons.
    Source Title
    Inorganic Chemical Biology: Principles, Techniques and Applications
    DOI
    10.1002/9781118682975.ch10
    ISBN
    9781118510025
    School
    Nanochemistry Research Institute
    URI
    http://hdl.handle.net/20.500.11937/12699
    Collection
    • Curtin Research Publications
    Abstract

    The biological activity of molecules is modulated by coordination to a transition metal centre. Ideally, this results in a completely inactive system, which acts as a prodrug, from which the bioactive component can be released by a specific trigger mechanism in a spatially and temporally controlled way. This chapter focuses on three different applications, to highlight general concepts as well as current challenges in the area: (1) the release of small-molecule messengers such as nitric oxide (NO) and carbon monoxide (CO) from the metal coordination sphere; (2) the "photouncaging" of organic neurotransmitters from metal complexes; and (3) the hypoxia-activated release of anticancer-active compounds from metal-based prodrugs.

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