Show simple item record

dc.contributor.authorSimpson, Peter
dc.contributor.authorSchatzschneider, U.
dc.date.accessioned2017-01-30T11:32:17Z
dc.date.available2017-01-30T11:32:17Z
dc.date.created2016-02-01T00:47:11Z
dc.date.issued2014
dc.identifier.citationSimpson, P. and Schatzschneider, U. 2014. Release of Bioactive Molecules Using Metal Complexes, in Gasser, G. (ed), Inorganic Chemical Biology: Principles, Techniques and Applications, pp. 309-339. Chichester: John Wiley & Sons.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/12699
dc.identifier.doi10.1002/9781118682975.ch10
dc.description.abstract

The biological activity of molecules is modulated by coordination to a transition metal centre. Ideally, this results in a completely inactive system, which acts as a prodrug, from which the bioactive component can be released by a specific trigger mechanism in a spatially and temporally controlled way. This chapter focuses on three different applications, to highlight general concepts as well as current challenges in the area: (1) the release of small-molecule messengers such as nitric oxide (NO) and carbon monoxide (CO) from the metal coordination sphere; (2) the "photouncaging" of organic neurotransmitters from metal complexes; and (3) the hypoxia-activated release of anticancer-active compounds from metal-based prodrugs.

dc.titleRelease of Bioactive Molecules Using Metal Complexes
dc.typeBook Chapter
dcterms.source.startPage309
dcterms.source.endPage339
dcterms.source.titleInorganic Chemical Biology: Principles, Techniques and Applications
dcterms.source.isbn9781118510025
curtin.departmentNanochemistry Research Institute
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record