Release of Bioactive Molecules Using Metal Complexes
dc.contributor.author | Simpson, Peter | |
dc.contributor.author | Schatzschneider, U. | |
dc.date.accessioned | 2017-01-30T11:32:17Z | |
dc.date.available | 2017-01-30T11:32:17Z | |
dc.date.created | 2016-02-01T00:47:11Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Simpson, P. and Schatzschneider, U. 2014. Release of Bioactive Molecules Using Metal Complexes, in Gasser, G. (ed), Inorganic Chemical Biology: Principles, Techniques and Applications, pp. 309-339. Chichester: John Wiley & Sons. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/12699 | |
dc.identifier.doi | 10.1002/9781118682975.ch10 | |
dc.description.abstract |
The biological activity of molecules is modulated by coordination to a transition metal centre. Ideally, this results in a completely inactive system, which acts as a prodrug, from which the bioactive component can be released by a specific trigger mechanism in a spatially and temporally controlled way. This chapter focuses on three different applications, to highlight general concepts as well as current challenges in the area: (1) the release of small-molecule messengers such as nitric oxide (NO) and carbon monoxide (CO) from the metal coordination sphere; (2) the "photouncaging" of organic neurotransmitters from metal complexes; and (3) the hypoxia-activated release of anticancer-active compounds from metal-based prodrugs. | |
dc.title | Release of Bioactive Molecules Using Metal Complexes | |
dc.type | Book Chapter | |
dcterms.source.startPage | 309 | |
dcterms.source.endPage | 339 | |
dcterms.source.title | Inorganic Chemical Biology: Principles, Techniques and Applications | |
dcterms.source.isbn | 9781118510025 | |
curtin.department | Nanochemistry Research Institute | |
curtin.accessStatus | Fulltext not available |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |