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dc.contributor.authorBondonno, C.
dc.contributor.authorLiu, A.
dc.contributor.authorCroft, K.
dc.contributor.authorWard, Natalie
dc.contributor.authorYang, X.
dc.contributor.authorConsidine, M.
dc.contributor.authorPuddey, I.
dc.contributor.authorWoodman, R.
dc.contributor.authorHodgson, J.
dc.date.accessioned2017-01-30T11:32:19Z
dc.date.available2017-01-30T11:32:19Z
dc.date.created2016-01-19T20:00:31Z
dc.date.issued2014
dc.identifier.citationBondonno, C. and Liu, A. and Croft, K. and Ward, N. and Yang, X. and Considine, M. and Puddey, I. et al. 2014. Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure. Free Radical Biology and Medicine. 77: pp. 353-362.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/12704
dc.identifier.doi10.1016/j.freeradbiomed.2014.09.021
dc.description.abstract

Evidence for a beneficial effect of dietary nitrate, through the nitrate–nitrite–NO pathway, on measures of cardiovascular function in healthy individuals is accumulating. It is less clear whether increased dietary nitrate intake from green leafy vegetables would have similar beneficial vascular effects in those at increased risk of developing hypertension. Our aim was to assess the effects of short-term regular consumption of increased nitrate from green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure. Thirty-eight men and women ages 30–70 years with systolic blood pressure 120 to 139 mm Hg were recruited to a randomized controlled crossover trial. The effects of a 7-day high-nitrate diet intervention (increased nitrate intake by at least 300 mg/day from green leafy vegetables) were compared to a 7-day low-nitrate diet intervention. Outcome measures included pre- and postintervention salivary and plasma nitrate and nitrite concentrations; ambulatory, home, and office blood pressure; augmentation index; and carotid–femoral pulse wave velocity. The high-nitrate diet intervention resulted in at least a fourfold increase in salivary and plasma nitrate and nitrite (P<0.001). Ambulatory, home, and office blood pressure and arterial stiffness were not different between the high-nitrate diet and the low-nitrate diet. Increasing dietary nitrate intake in those with high-normal blood pressure and at increased risk of hypertension may not be an effective short-term strategy to lower blood pressure.

dc.titleShort-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure
dc.typeJournal Article
dcterms.source.volume77
dcterms.source.startPage353
dcterms.source.endPage362
dcterms.source.issn0891-5849
dcterms.source.titleFree Radical Biology and Medicine
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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