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    NF-κB in cancer therapy

    Access Status
    Fulltext not available
    Authors
    Li, F.
    Zhang, J.
    Arfuso, Frank
    Chinnathambi, A.
    Zayed, M.
    Alharbi, S.
    Kumar, Alan Prem
    Ahn, K.
    Sethi, G.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Li, F. and Zhang, J. and Arfuso, F. and Chinnathambi, A. and Zayed, M. and Alharbi, S. and Kumar, A. et al. 2015. NF-κB in cancer therapy. Archives of Toxicology. 89 (5): pp. 711-731.
    Source Title
    Archives of Toxicology
    DOI
    10.1007/s00204-015-1470-4
    ISSN
    0340-5761
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/12782
    Collection
    • Curtin Research Publications
    Abstract

    The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.

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