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dc.contributor.authorLi, F.
dc.contributor.authorZhang, J.
dc.contributor.authorArfuso, Frank
dc.contributor.authorChinnathambi, A.
dc.contributor.authorZayed, M.
dc.contributor.authorAlharbi, S.
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorAhn, K.
dc.contributor.authorSethi, G.
dc.date.accessioned2017-01-30T11:32:48Z
dc.date.available2017-01-30T11:32:48Z
dc.date.created2015-10-29T04:09:55Z
dc.date.issued2015
dc.identifier.citationLi, F. and Zhang, J. and Arfuso, F. and Chinnathambi, A. and Zayed, M. and Alharbi, S. and Kumar, A. et al. 2015. NF-κB in cancer therapy. Archives of Toxicology. 89 (5): pp. 711-731.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/12782
dc.identifier.doi10.1007/s00204-015-1470-4
dc.description.abstract

The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.

dc.publisherSpringer Verlag
dc.titleNF-κB in cancer therapy
dc.typeJournal Article
dcterms.source.issn0340-5761
dcterms.source.titleArchives of Toxicology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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