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    Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents

    163613_40120_Dolzhenko_manuscript_revised.pdf (148.8Kb)
    Access Status
    Open access
    Authors
    Dolzhenko, Anton
    Foo, M.
    Tan, B.
    Dolzhenko, A.
    Chiu, G.
    Chui, W.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Dolzhenko, Anton V. and Foo, Mi Chelle. and Tan, Ben Jee. and Dolzhenko, Anna V. and Chiu, Gigi Ngar Chee. and Chui, Wai Keung. 2009. Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents. Heterocycles. 78 (7): pp. 1761-1775.
    Source Title
    Heterocycles
    ISSN
    1881-0942
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/13442
    Collection
    • Curtin Research Publications
    Abstract

    The cyclocondensations of 3,4-dihydroquinazolin-2-yl guanidine with a variety of electrophilic reagents viz. aldehydes, ketones, triethyl orthoformate, diethyl ethoxymethylenemalonate, carbon disulfide and trichloroacetonitrile were found to afford 1,3,5-triazino[2,1-b]quinazolines. However, some unexpected reactions were also observed. The structural properties such as tautomerism and hinderance to conformational rotation were also investigated. The results of biological testing suggested that the 1,3,5-triazino[2,1-b]quinazoline nucleus could be a new promising scaffold for the development of potential anticancer agents.

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