Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents
dc.contributor.author | Dolzhenko, Anton | |
dc.contributor.author | Foo, M. | |
dc.contributor.author | Tan, B. | |
dc.contributor.author | Dolzhenko, A. | |
dc.contributor.author | Chiu, G. | |
dc.contributor.author | Chui, W. | |
dc.date.accessioned | 2017-01-30T11:37:09Z | |
dc.date.available | 2017-01-30T11:37:09Z | |
dc.date.created | 2011-08-17T20:01:14Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Dolzhenko, Anton V. and Foo, Mi Chelle. and Tan, Ben Jee. and Dolzhenko, Anna V. and Chiu, Gigi Ngar Chee. and Chui, Wai Keung. 2009. Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents. Heterocycles. 78 (7): pp. 1761-1775. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/13442 | |
dc.description.abstract |
The cyclocondensations of 3,4-dihydroquinazolin-2-yl guanidine with a variety of electrophilic reagents viz. aldehydes, ketones, triethyl orthoformate, diethyl ethoxymethylenemalonate, carbon disulfide and trichloroacetonitrile were found to afford 1,3,5-triazino[2,1-b]quinazolines. However, some unexpected reactions were also observed. The structural properties such as tautomerism and hinderance to conformational rotation were also investigated. The results of biological testing suggested that the 1,3,5-triazino[2,1-b]quinazoline nucleus could be a new promising scaffold for the development of potential anticancer agents. | |
dc.publisher | The Japan Institute of Heterocyclic Chemistry | |
dc.title | Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents | |
dc.type | Journal Article | |
dcterms.source.volume | 78 | |
dcterms.source.number | 7 | |
dcterms.source.startPage | 1761 | |
dcterms.source.endPage | 1775 | |
dcterms.source.issn | 1881-0942 | |
dcterms.source.title | Heterocycles | |
curtin.department | School of Pharmacy | |
curtin.accessStatus | Open access |