The effect of cell culture on X chromosome mosaicism
|dc.contributor.author||Patton, Kirralee Anne|
|dc.contributor.supervisor||Dr Ashleigh Murch|
|dc.contributor.supervisor||Prof. John Wetherall|
|dc.contributor.supervisor||Dr Narelle Hadlow|
The effects of cell culture on X chromosome aneuploidy in young women with established fertility were investigated. Fluorescence in situ hybridisation was performed on paired samples of mitogen stimulated and uncultured lymphocytes using probes for the X and 9 chromosomes. All participants had <5% X aneuploidy in both preparations. X chromosome loss occurred more frequently than gain. These results provide important information when interpreting the low levels of X mosaicism seen in routine cytogenetic practice.
|dc.title||The effect of cell culture on X chromosome mosaicism|
|curtin.department||School of Biomedical Science|