Creating a protein ontology resource
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Copyright 2005 IEEE
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Protein Data Integration approaches at the moment considers data sources as data repositories, but not as applications; which in turn may embody complex interactions with other data sources. Current approaches do not provide methods both for generic mapping protein data representation, depicting interactions in data it describes and for interfacing existing data. The proposed Protein Ontology shows the value of hierarchy and relationships present in proteomics data. The creation of a Protein Ontology provides understanding of diverse types of data like:(1) Protein Entry Details(2) 3D Structural Representations of Proteins(3) Structural Folds and domains conserved in proteins(4) Functional Domains and Families created based on Physiological and Pathological Functions of Proteins, and(5) Various Constraints like Genetic Defects and Chemical Properties of Cell that affect Final Stable Molecular Structure of Protein.Protein Ontology describes the concepts of interest in protein complex mechanisms and proteomics process.
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Dillon, Tharam S.; Sidhu, Amandeep; Chang, Elizabeth (2005)In this paper, we proposed a Protein Ontology to integrate protein data and information from various Protein Data Sources. Protein Ontology provides the technical and scientific infrastructure and knowledge to allow ...
Chang, Elizabeth; Sidhu, Amandeep; Sidhu, B.; Dillon, Tharam S. (2005)The rapid generation of accessible protein data sources has generated confusion over protein data representation. The protein ontology project seeks to provide a set of structured vocabularies for protein domains that can ...
Sidhu, Amandeep; Dillon, Tharam S.; Chang, Elizabeth (2007)These Huge amounts of Protein Structure Data make it difficult to create explanatory and predictive models that are consistent with huge volume of data. Difficulty increase when large variety of heterogeneous approaches ...