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    Proportion of Undercarboxylated Osteocalcin and Serum P1NP Predict Incidence of Myocardial Infarction in Older Men.

    Access Status
    Open access via publisher
    Authors
    Yeap, B.
    Alfonso, Helman
    Chubb, S.
    Byrnes, E.
    Beilby, J.
    Ebeling, P.
    Allan, C.
    Schultz, C.
    Hankey, G.
    Golledge, J.
    Flicker, L.
    Norman, P.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Yeap, B. and Alfonso, H. and Chubb, S. and Byrnes, E. and Beilby, J. and Ebeling, P. and Allan, C. et al. 2015. Proportion of Undercarboxylated Osteocalcin and Serum P1NP Predict Incidence of Myocardial Infarction in Older Men.. J Clin Endocrinol Metab. 100 (10): pp. 3934-3942.
    Source Title
    J Clin Endocrinol Metab
    DOI
    10.1210/jc.2015-1899
    School
    Epidemiology and Biostatistics
    URI
    http://hdl.handle.net/20.500.11937/13664
    Collection
    • Curtin Research Publications
    Abstract

    CONTEXT: Undercarboxylated osteocalcin (ucOC) modulates insulin secretion and sensitivity in mice, and higher ucOC is associated with lower prevalence of diabetes in men. The influence of ucOC distinct from other markers of bone turnover on incidence of cardiovascular events is unclear. PARTICIPANTS: Community-dwelling men aged 70-89 years resident in Perth, Western Australia. MAIN OUTCOME MEASURES: Serum total osteocalcin (TOC), N-terminal propeptide of type I collagen (P1NP), and collagen type I C-terminal cross-linked telopeptide (CTX) were measured by immunoassay, and ucOC by hydroxyapatite binding. The ratio ucOC/TOC was calculated. Hospital admissions and deaths from myocardial infarction (MI) and stroke were ascertained. RESULTS: There were 3384 men followed for 7.0 years, during which 293 experienced an MI, 251 stroke, and 2840 neither. In multivariate analyses, higher ratio of ucOC/TOC (expressed as %) was associated with lower incidence of MI (quartiles Q2-4, =49% versus Q1,<49%, hazard ratio 0.70, 95% confidence interval = 0.54-0.91), but not of stroke (0.99, 0.73-1.34). Higher P1NP was associated with higher incidence of MI (Q2-4, =28.2 µg/L versus Q1, <28.2 µg/L, hazard ratio 1.45, 95% confidence interval = 1.06-1.97), but not of stroke (0.94, 0.70-1.26). CTX was not associated with incident MI or stroke. CONCLUSIONS: A reduced proportion of undercarboxylated osteocalcin or higher P1NP are associated with increased incidence of MI. UcOC/TOC ratio and P1NP predict risk of MI but not stroke, in a manner distinct from CTX. Further studies are needed to investigate potential mechanisms by which bone turnover markers related to metabolic risk and to collagen formation could modulate cardiovascular risk.

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