Show simple item record

dc.contributor.authorChen, Y.
dc.contributor.authorCruzat, Vinicius
dc.contributor.authorNewsholme, P.
dc.identifier.citationChen, Y. and Cruzat, V. and Newsholme, P. 2016. β-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes, in Mauricio, D. (ed), Molecular Nutrition and Diabetes, pp. 29-40. London: Academic Press.

Located in the islets of Langerhans of the pancreas, β cells perform essential hormone secretory functions that affect metabolism. Nutrients are potent regulators of β-cell insulin secretion, which is essential to the organism. In the past few decades, changes in lifestyle, especially related to overnutrition, has increased the global incidence of obesity-associated diabetes. In this scenario, impairment to β-cell function may lead to failure and gradual progression to type 2 diabetes. Multiple molecular pathways have been identified that contribute to dysfunction associated with glucotoxicity and lipotoxicity. Recent in vitro and in vivo studies have led to a better understanding of the complexities of β-cell dysfunction and how it interferes in the pathways of insulin secretion and action. New therapeutic strategies targeting the molecules sensitive and responsive to cell nutrition in the context of diabetes present new opportunities and are presented in the present chapter.

dc.publisherWiley - V C H Verlag GmbH
dc.titleβ-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes
dc.typeBook Chapter
dcterms.source.volumeA Volume in the Molecular Nutrition Series
dcterms.source.titleMolecular Nutrition and Food research
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record