Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway
MetadataShow full item record
Caffeine is a naturally occurring methylxanthine that acts as a non-selective adenosine receptor antagonist. Epidemiological studies demonstrated habitual coffee drinking to be significantly associated with liver cancer survival. We aimed to investigate the effects of caffeine and its analog CGS 15943 on hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC). We demonstrate that caffeine and CGS 15943 block proliferation in HCC and PDAC cell lines by inhibiting the PI3K/Akt pathway. Importantly a kinase profiling assay reveals that CGS 15943 targets specifically the catalytic subunit of the class IB PI3K isoform (p110ƴ). These data give mechanistic insight into the action of caffeine and its analogs and they identify these compounds as promising lead compounds to develop drugs that can specifically target this PI3K isoform whose key role in cancer progression is emerging.
Showing items related by title, author, creator and subject.
Joshi, Paliza (2011)Objectives: The purpose of this study was to determine the prevalence and patterns of use of cognitive enhancing substances (such as caffeine containing products and beverages and prescription stimulant drugs) amongst ...
Use of caffeinated substances and risk of crashes in long distance drivers of commercial vehicles: case-control studySharwood, L.; Elkington, J.; Meuleners, Lynn; Ivers, R.; Boufous, S.; Stevenson, M. (2013)Objective: To determine whether there is an association between use of substances that contain caffeine and the risk of crash in long distance commercial vehicle drivers.Design: Case-control studySetting: New South Wales ...
Hirayama, Fumi; Lee, Andy; Yasukawa, K.; Ishihara, Y.; Shinjo, M. (2012)Background: To investigate the association between caffeine intake and the risk of developing chronic obstructive pulmonary disease (COPD) among Japanese older adults, a case–control study was conducted in central Japan. ...