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dc.contributor.authorEdling, C.
dc.contributor.authorSelvaggi, F.
dc.contributor.authorGhonaim, R.
dc.contributor.authorMaffucci, T.
dc.contributor.authorFalasca, Marco
dc.date.accessioned2017-01-30T11:40:03Z
dc.date.available2017-01-30T11:40:03Z
dc.date.created2015-04-09T09:08:01Z
dc.date.issued2014
dc.identifier.citationEdling, C. and Selvaggi, F. and Ghonaim, R. and Maffucci, T. and Falasca, M. 2014. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biology and Therapy. 15 (5): pp. 524-532.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/13886
dc.identifier.doi10.4161/cbt.28018
dc.description.abstract

Caffeine is a naturally occurring methylxanthine that acts as a non-selective adenosine receptor antagonist. Epidemiological studies demonstrated habitual coffee drinking to be significantly associated with liver cancer survival. We aimed to investigate the effects of caffeine and its analog CGS 15943 on hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC). We demonstrate that caffeine and CGS 15943 block proliferation in HCC and PDAC cell lines by inhibiting the PI3K/Akt pathway. Importantly a kinase profiling assay reveals that CGS 15943 targets specifically the catalytic subunit of the class IB PI3K isoform (p110ƴ). These data give mechanistic insight into the action of caffeine and its analogs and they identify these compounds as promising lead compounds to develop drugs that can specifically target this PI3K isoform whose key role in cancer progression is emerging.

dc.publisherLandes Bioscience
dc.subjectphosphoinositide 3-kinase
dc.subjectcaffeine
dc.subjectCGS 15943
dc.subjectpancreatic ductal adenocarcinoma
dc.subjecthepatocellular carcinoma
dc.titleCaffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway
dc.typeJournal Article
dcterms.source.volume15
dcterms.source.number5
dcterms.source.startPage524
dcterms.source.endPage532
dcterms.source.issn1538-4047
dcterms.source.titleCancer Biology and Therapy
curtin.accessStatusOpen access via publisher


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