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    Diagnostic accuracy of 64 multislice CT angiography in the assessment of coronary in-stent restenosis: A meta-analysis

    217717_217717.pdf (103.1Kb)
    Access Status
    Open access
    Authors
    Sun, Zhonghua
    Almutairi, Abdulrahman
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Sun, Z. and Almutairi, A. 2010. Diagnostic accuracy of 64 multislice CT angiography in the assessment of coronary in-stent restenosis: A meta-analysis. European Journal of Radiology. 73 (2): pp. 266-273.
    Source Title
    European Journal of Radiology
    DOI
    10.1016/j.ejrad.2008.10.025
    ISSN
    0720-048X
    School
    Department of Physics and Astronomy
    Remarks

    NOTICE: This is the author’s version of a work that was accepted for publication in European Journal of Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Radiology [73 (2) 2010] DOI 10.1016/j.ejrad.2008.10.025

    URI
    http://hdl.handle.net/20.500.11937/13899
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: The aim of this study was to perform a meta-analysis of the diagnostic accuracy of 64-slice CT angiography for evaluation of coronary stent restenosis in patients treated with coronary stents when compared to conventional coronary angiography. Materials and Methods: A search of PUBMED/MEDLINE databases for English literature was performed. Only studies comparing 64-slice CT angiography with conventional coronary angiography for the detection of coronary in-stent restenosis (more than 50% stenosis) were included for analysis. Sensitivity and specificity estimates pooled across studies were tested using a fixed effects model. Fourteen studies met selection criteria for inclusion in the analysis. The mean value of assessable stents was 89%. Prevalence of in-stent restenosis following coronary stenting was 20% among these studies. Pooled estimates of the sensitivity and specificity of overall 64-slice CT angiography for the detection of coronary instent restenosis was 90% (95% CI: 86%, 94%) and 91% (95% CI: 90%, 93%), respectively, based on the evaluation of assessable stents. Diagnostic value of 64-slice CT angiography was found to decrease significantly when the analysis was performed with inclusion of nonassessable segments in five studies, with pooled sensitivity and specificity being 79% (95% CI: 68%, 88%) and 81% (95% CI: 77%, 84%). Stent diameter is the main factor affecting the diagnostic value of MSCT angiography. Conclusion: Our results showed that 64-slice CT angiography has high diagnostic value (both sensitivity and specificity) for detection of coronary in-stent restenosis based on assessable segments when compared to conventional coronary angiography.

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