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    Multislice CT angiography in the assessment of coronary artery in-stent restenosis: A systematic review.

    20469_downloaded_stream_457.pdf (92.50Kb)
    Access Status
    Open access
    Authors
    Sun, Zhonghua
    Davidson, R.
    Lin, C.
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Sun, Zhonghua and Davidson, Robert and Lin, Cheung HSun. 2008. Multislice CT angiography in the assessment of coronary artery in-stent restenosis: A systematic review. Article in Press, Corrected Proof . European Journal of Radiology.
    Source Title
    European Journal of Radiology
    DOI
    10.1016/j.ejrad.2007.11.030
    Faculty
    Division of Engineering, Science and Computing
    School
    Discipline of Medical Imaging Science
    Remarks

    Copyright 2008 Elsevier B.V. All rights reserved

    URI
    http://hdl.handle.net/20.500.11937/3193
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: The aim of this study was to perform a systematic review of the diagnostic accuracy of multi-detector row computed tomography angiography (MDCT) for detection of coronary in-stent restenosis in patients treated with coronary stenting when compared to invasive catheter angiography.Materials and Methods: A search of PUBMED and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing 16- or more detector rows MDCT angiography with invasive catheter angiography in the detection of coronary in-stent restenosis (more than 50% stenosis) were included for analysis. Sensitivity and specificity estimates pooled across studies were tested using a fixed effects model.Results: 15 studies met selection criteria for inclusion in the analysis. There were eight studies performed with 16-detector row CT scanners, and five studies with 64-detector row scanners and one study with a 40-detector scanner. The remaining study was performed with a mixture of 16-and 64-detector row scanners. Prevalence of in-stent restenosis following coronary stenting was 18% (95% CI: 13%, 24%). Pooled estimates of the sensitivity and specificity of overall MDCT angiography for the detection of coronary in-stent restenosis was 85% (95% CI: 78%, 90%) and 97% (95% CI: 95%, 98%), respectively. No significant difference was found between 16- and 64-detector row scanners regarding the sensitivity and specificity of MDCT for assessment of in-stent restenosis (p>0.05).Conclusion: The results showed that MDCT angiography (with 16 or more detector rows) has moderate sensitivity and high specificity for the detection of coronary in-stent restenosis when compared to invasive catheter angiography. A high specificity value of MDCT may be most valuable as a non-invasive technique of excluding coronary stent restenosis or occlusion. The main factors affecting visualization are stent diameters and stent materials.

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