TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians
MetadataShow full item record
Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies. © 2013 Macmillan Publishers Limited.
Showing items related by title, author, creator and subject.
TNF block haplotypes reveal diverse pathways between TNF and disease: Implications for understanding neuropathy in HIV patientsChew, C.; Valente, F.; Wallace, H.; Tan, J.; Temple, S.; Price, Patricia (2012)The region spanning the tumor necrosis factor (TNF) cluster in the human major histocompatibility complex (MHC) has been implicated in susceptibility to numerous immunopathological and inflammatory diseases. However, ...
Tan, J.; Temple, S.; Kee, C.; Waterer, G.; Tan, C.; Gut, I.; Price, Patricia (2011)Polymorphisms in the central major histocompatibility complex (MHC) (particularly TNF and adjacent genes) associate with several immunopathological diseases and with susceptibility to pneumonia. The MHC is characterised ...
Chloroplast DNA diversity associated with protected slopes and valleys for hybridizing Eucalyptus species on isolated ranges in south-eastern AustraliaPollock, L.; Bayly, M.; Nevill, Paul; Vesk, P. (2013)Aim To relate genetic diversity to topographic features and to investigate genetic interactions between Eucalyptus species in a local centre of endemism and diversity in south-eastern Australia. Location Grampian Ranges, ...