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TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians

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Authors
Chew, C.
Wadley, A.
Lombard, Z.
Kamerman, P.
Price, Patricia
Date
2013
Type
Journal Article

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Chew, C. and Wadley, A. and Lombard, Z. and Kamerman, P. and Price, P. 2013. TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians. Genes and Immunity. 14 (4): pp. 268-270.
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Genes and Immunity
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School of Biomedical Sciences
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Abstract

Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies. © 2013 Macmillan Publishers Limited.