TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians
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Authors
Chew, C.
Wadley, A.
Lombard, Z.
Kamerman, P.
Price, Patricia
Date
2013Type
Journal Article
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Chew, C. and Wadley, A. and Lombard, Z. and Kamerman, P. and Price, P. 2013. TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians. Genes and Immunity. 14 (4): pp. 268-270.
Source Title
Genes and Immunity
ISSN
School
School of Biomedical Sciences
Collection
Abstract
Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies. © 2013 Macmillan Publishers Limited.
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