The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
MetadataShow full item record
The biogenesis and accumulation of the beta amyloid protein (Aß) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer’s disease. The presenilins and its interacting proteins play a pivotal role in the generation of Aß from the amyloid precursor protein (APP). In particular, three proteins (nicastrin, aph-1 and pen-2) interact with presenilins to form a large multi-subunit enzymatic complex (?-secretase) that cleaves APP to generate Aß. Reconstitution studies in yeast and insect cells have provided strong evidence that these four proteins are the major components of the ?-secretase enzyme. Current research is directed at elucidating the roles that each of these protein play in the function of this enzyme. In addition, a number of presenilin interacting proteins that are not components of ?-secretase play important roles in modulating Aß production. This review will discuss the components of the ?-secretase complex and the role of presenilin interacting proteins on ?-secretase activity.
Showing items related by title, author, creator and subject.
Evidence for and against a pathogenic role for reduced γ-secretase activity in familial Alzheimer’s diseaseVerdile, Giuseppe; Jayne, T.; Newman, M.; Sutherland, G.; Munch, G.; Musgrave, I.; Moussavi Nik, H.; Lardelli, M. (2016)The majority of mutations causing familial Alzheimer’s disease (fAD) have been found in the gene PRESENILIN1 (PSEN1 ) with additional mutations in the related gene PRESENILIN2 (PSEN2 ). The best characterized function of ...
Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of ?-secretase activityNik, S.; Newman, M.; Wilson, L.; Ebrahimie, E.; Wells, S.; Musgrave, I.; Verdile, Giuseppe; Martins, R.; Lardelli, M. (2015)The PRESENILIN1 and PRESENILIN2 genes encode structurally related proteases essential for ?-secretase activity. Of nearly 200 PRESENILIN mutations causing early onset, familial Alzheimer's disease (FAD) only the K115Efx10 ...
Disruption of blood-brain barrier function by chronic intake of saturated fat and cholesterol : implications for Alzheimer’s disease riskTakechi, Ryusuke (2010)It has been reported that lifestyle including diet is associated with Alzheimer’s disease (AD) risk and progression. Population studies indicate that the chronic consumption of diets enriched in saturated fats (SFA) and ...