Prediction of cardiovascular and all-cause mortality at 10 years in the hypertensive aged population
MetadataShow full item record
© American Journal of Hypertension, Ltd 2014. All rights reserved. Background We have previously developed a score for predicting cardiovascular events in the intermediate term in an elderly hypertensive population. In this study, we aimed to extend this work to predict 10-year cardiovascular and all-cause mortality in the hypertensive aged population. Methods Ten-year follow-up data of 5,378 hypertensive participants in the Second Australian National Blood Pressure study who were aged 65-84 years at baseline (1995-2001) and without prior cardiovascular events were analyzed. By using bootstrap resampling variable selection methods and comparing the Akaike and Bayesian information criterion and C-indices of the potential models, optimal and parsimonious multivariable Cox proportional hazards models were developed to predict 10-year cardiovascular and all-cause mortality. The models were validated using bootstrap validation method internally and using the Dubbo Study dataset externally. Results The final model for cardiovascular mortality included detrimental (age, smoking, diabetes, waist-hip ratio, and disadvantaged socioeconomic status) and protective factors (female sex, alcohol consumption, and physical activity). The final model for all-cause mortality also included detrimental (age, smoking, random blood glucose, and disadvantaged socioeconomic status) and protective factors (female sex, alcohol consumption, body mass index, and statin use). Blood pressure did not appear in either model in this patient group. The C-statistics for internal validation were 0.707 (cardiovascular mortality) and 0.678 (all-cause mortality), and for external validation were 0.729 (cardiovascular mortality) and 0.772 (all-cause mortality). Conclusions These algorithms allow reliable estimation of 10-year risk of cardiovascular and all-cause mortality for hypertensive aged individuals.
Showing items related by title, author, creator and subject.
Smoking-associated DNA methylation biomarkers and their predictive value for all-cause and cardiovascular mortalityZhang, Y.; Schöttker, B.; Florath, Ines; Stock, C.; Butterbach, K.; Holleczek, B.; Mons, U.; Brenner, H. (2016)Background: With epigenome-wide mapping of DNA methylation, a number of novel smoking-associated loci have been identified. Objectives: We aimed to assess dose–response relationships of methylation at the top hits from ...
Ten-year legacy effects of baseline blood pressure 'treatment naivety' in the Second Australian National Blood Pressure studyNelson, M.; Chowdhury, E.; Doust, J.; Reid, Christopher; Wing, L. (2015)© 2015 Wolters Kluwer Health, Inc. All rights reserved. Objectives: Current blood pressure (BP) management guidelines recommend that treatment thresholds for BP be based on absolute cardiovascular disease (CVD) risk rather ...
Short-and long-term survival in treated elderly hypertensive patients with or without diabetes: Findings from the second Australian national blood pressure studyChowdhury, E.; Owen, A.; Ademi, Z.; Krum, H.; Johnston, C.; Wing, L.; Nelson, M.; Reid, Christopher (2014)Background: We sought to determine the incidence of newly diagnosed diabetes in treated elderly hypertensive patients and the prognostic impact of diabetes on long-term survival. Methods: The Second Australian National ...