Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Smoking-associated DNA methylation biomarkers and their predictive value for all-cause and cardiovascular mortality

    Access Status
    Open access via publisher
    Authors
    Zhang, Y.
    Schöttker, B.
    Florath, Ines
    Stock, C.
    Butterbach, K.
    Holleczek, B.
    Mons, U.
    Brenner, H.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Zhang, Y. and Schöttker, B. and Florath, I. and Stock, C. and Butterbach, K. and Holleczek, B. and Mons, U. et al. 2016. Smoking-associated DNA methylation biomarkers and their predictive value for all-cause and cardiovascular mortality. Environmental Health Perspectives. 124 (1): pp. 67-74.
    Source Title
    Environmental Health Perspectives
    DOI
    10.1289/ehp.1409020
    ISSN
    0091-6765
    School
    Epidemiology and Biostatistics
    URI
    http://hdl.handle.net/20.500.11937/42892
    Collection
    • Curtin Research Publications
    Abstract

    Background: With epigenome-wide mapping of DNA methylation, a number of novel smoking-associated loci have been identified. Objectives: We aimed to assess dose–response relationships of methylation at the top hits from the epigenome-wide methylation studies with smoking exposure as well as with total and cause-specific mortality. Methods: In a population-based prospective cohort study in Germany, methylation was quantified in baseline blood DNA of 1,000 older adults by the Illumina 450K assay. Deaths were recorded during a median follow-up of 10.3 years. Dose–response relationships of smoking exposure with methylation at nine CpGs were modeled by restricted cubic spline regression. Associations of individual and aggregate methylation patterns with all-cause, cardiovascular, and cancer mortality were assessed by multiple Cox regression. Results: Clear dose–response relationships with respect to current and lifetime smoking intensity were consistently observed for methylation at six of the nine CpGs. Seven of the nine CpGs were also associated with mortality outcomes to various extents. A methylation score based on the top two CpGs (cg05575921 and cg06126421) showed the strongest associations with all-cause, cardiovascular, and cancer mortality, with adjusted hazard ratios (95% CI) of 3.59 (2.10, 6.16), 7.41 (2.81, 19.54), and 2.48 (1.01, 6.08), respectively, for participants with methylation levels in the lowest quartile at both CpGs. Adding methylation at those two CpGs into a model that included the variables of the Systematic Coronary Risk Evaluation chart for fatal cardiovascular risk prediction improved the predictive discrimination.Conclusion: The novel methylation biomarkers are highly informative for both smoking exposure and smoking-related mortality outcomes. In particular, these biomarkers may substantially improve cardiovascular risk prediction. Nevertheless, the findings of the present study need to be further validated in additional large longitudinal studies.

    Related items

    Showing items related by title, author, creator and subject.

    • Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults
      Melton, Phillip (2018)
      © 2018 The Authors Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links ...
    • Self-reported smoking, serum cotinine, and blood DNA methylation
      Zhang, Y.; Florath, Ines; Saum, K.; Brenner, H. (2016)
      BACKGROUND: Epigenome-wide profiling of DNA methylation pattern with respect to tobacco smoking has given rise to a new measure of smoking exposure. We investigated the relationships of methylation markers with both ...
    • Prediction of cardiovascular and all-cause mortality at 10 years in the hypertensive aged population
      Huynh, Q.; Reid, Christopher; Chowdhury, E.; Huq, M.; Billah, B.; Wing, L.; Tonkin, A.; Simons, L.; Nelson, M.; Beilin, L.; Jennings, G.; Johnston, C.; Macdonald, G.; Marley, J.; McNeil, J.; Morgan, T.; Ryan, P.; West, M. (2015)
      © American Journal of Hypertension, Ltd 2014. All rights reserved. Background We have previously developed a score for predicting cardiovascular events in the intermediate term in an elderly hypertensive population. In ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.