Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers

    Access Status
    Open access via publisher
    Authors
    Moore, B.
    Salman, S.
    Benjamin, J.
    Page-Sharp, Madhu
    Yadi, G.
    Batty, Kevin
    Siba, P.
    Mueller, I.
    Davis, T.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Moore, B. and Salman, S. and Benjamin, J. and Page-Sharp, M. and Yadi, G. and Batty, K. and Siba, P. et al. 2015. Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers. Antimicrobial Agents and Chemotherapy. 59 (7): pp. 4272-4278.
    Source Title
    Antimicrobial Agents and Chemotherapy
    DOI
    10.1128/AAC.00327-15
    ISSN
    0066-4804
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/14420
    Collection
    • Curtin Research Publications
    Abstract

    Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydro-artemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was sampled on days 1, 2, 3 to 5, 7 to 11, and 14 to 17 postdelivery, a median of 70 days postdose (range, 6 to 145 days). A blood sample was taken at delivery, and additional serial samples were available from 9 women who delivered within 42 days of dosing. Milk and plasma PQ were assayed by high-performance liquid chromatography. A population-based approach was used to model the log<inf>e</inf>(plasma) and milk concentration-time data. A sigmoid E<inf>max</inf> model best described PQ breast milk transfer. The population average milk: plasma PQ ratio was 0.58, with a peak of 2.5 at delivery. The model-derived maximum milk intake (148 ml/kg of body weight/day) was similar to the accepted value of 150 ml/kg/day. The median estimated absolute and relative cumulative infant PQ doses were 22 µg and 0.07%, respectively, corresponding to absolute and relative daily doses of 0.41 µg/kg and 0.004%. Model-based simulations for PQ treatment regimens given at birth, 1 week postdelivery, and 6 weeks postdelivery showed that the highest median estimated relative total infant dose (0.36%; median absolute total dose of 101 µg/kg) was seen after maternal PQ treatment 6 weeks postpartum. The maximum simulated relative total and daily doses from any scenario were 4.3% and 2.5%, respectively, which were lower than the recommended 10% upper limit. Piperaquine is transferred into breast milk after maternal treatment doses, but PQ exposure for suckling infants appears safe.

    Related items

    Showing items related by title, author, creator and subject.

    • Pharmacokinetics of transfer of azithromycin into the breast milk of African mothers
      Salman, S.; Davis, T.; Page-Sharp, Madhu; Camara, B.; Oluwalana, C.; Bojang, A.; D'Alessandro, U.; Roca, A. (2016)
      Azithromycin (AZI) is used for its antibiotic and antimalarial properties in pregnancy. Reported estimates of AZI breast milk transfer, based on concentrations in single samples from small numbers of women, have suggested ...
    • Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
      Salman, S.; Sy, S.; Ilett, K.; Page-Sharp, Madhu; Paech, M. (2011)
      Purpose: The aim of this investigation was to demonstrate that nonlinear mixed-effects population pharmacokinetic (PK) modeling can be used to evaluate data from studies of drug transport/excretion into human milk and ...
    • Estimated dose exposure of the neonate to buprenorphine and its metabolite norbuprenorphine via breastmilk during maternal buprenorphine substitution treatment
      Ilett, K.; Hackett, L.; Gower, Shelley; Doherty, D.; Hamilton, D.; Bartu, Anne (2012)
      Objective: The aim of the present study was to estimate the dose of buprenorphine and its primary metabolite norbuprenorphine that a breastfed infant would receive during maternal maintenance treatment with buprenorphine. ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.