Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

    Access Status
    Fulltext not available
    Authors
    Salman, S.
    Sy, S.
    Ilett, K.
    Page-Sharp, Madhu
    Paech, M.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Salman, Sam and Sy, Sherwin and Ilett, Kenneth and Page-Sharp, Madhu and Paech, Michael. 2011. Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk. European Journal of Clinical Pharmacology. 67 (9): pp. 899-908.
    Source Title
    European Journal of Clinical Pharmacology
    DOI
    10.1007/s00228-011-1023-6
    ISSN
    0031-6970
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/23482
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: The aim of this investigation was to demonstrate that nonlinear mixed-effects population pharmacokinetic (PK) modeling can be used to evaluate data from studies of drug transport/excretion into human milk and hence to estimate infant exposure. Methods: A sparse dataset from a previously published study of the use of oral tramadol for post-cesarean pain management in 75 lactating women was used. Milk and plasma samples were collected during days 2–4 of lactation, and tramadol and O-desmethyltramadol (ODT) concentration measurements in these samples were available. Absolute infant dose was obtained from the concentration measurements and estimated milk volume ingested, and expressed in micrograms per kilogram per day. Relative infant dose was calculated as a percentage of the absolute infant dose divided by the maternal dose (μg/kg/day). Nonlinear mixed-effects modeling was used to fit a population PK model to the data. Results: The disposition of tramadol and ODT in plasma and the transition of these substances into milk were characterized by a five-compartment population PK mixture model with first-order absorption. The polymorphic ODT formation clearance in the plasma compartment was able to be characterized in both CYP2D6-poor and -extensive metabolizers. Milk creamatocrit was a significant covariate in ODT transfer between the plasma and milk compartments. The estimated relative infant doses in extensive and poor metabolizers, respectively, were 2.16±0.57 and 2.60±0.57% for tramadol, and 0.93 ± .20 and 0.47±0.10% for ODT. Conclusions: This study demonstrates that a population PK approach with sparse sampling of analytes in milk and plasma can yield quality information about the transfer process and that it also can be used to estimate the extent of infant exposure to maternal drugs via milk.

    Related items

    Showing items related by title, author, creator and subject.

    • Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers
      Moore, B.; Salman, S.; Benjamin, J.; Page-Sharp, Madhu; Yadi, G.; Batty, Kevin; Siba, P.; Mueller, I.; Davis, T. (2015)
      Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydro-artemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was ...
    • Pharmacokinetics of transfer of azithromycin into the breast milk of African mothers
      Salman, S.; Davis, T.; Page-Sharp, Madhu; Camara, B.; Oluwalana, C.; Bojang, A.; D'Alessandro, U.; Roca, A. (2016)
      Azithromycin (AZI) is used for its antibiotic and antimalarial properties in pregnancy. Reported estimates of AZI breast milk transfer, based on concentrations in single samples from small numbers of women, have suggested ...
    • Estimated dose exposure of the neonate to buprenorphine and its metabolite norbuprenorphine via breastmilk during maternal buprenorphine substitution treatment
      Ilett, K.; Hackett, L.; Gower, Shelley; Doherty, D.; Hamilton, D.; Bartu, Anne (2012)
      Objective: The aim of the present study was to estimate the dose of buprenorphine and its primary metabolite norbuprenorphine that a breastfed infant would receive during maternal maintenance treatment with buprenorphine. ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.